ArticleProceedings of the National Academy of Sciences of the United States of America2004
A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Genetic and environmental determinants of streaming and aggregation in Myxococcus xanthus.Scientific reports · 2025Article
- The Limits of Our Explanation: A Case Study inBiological theory · 2025Article
- A general model-based causal inference method overcomes the curse of synchrony and indirect effect.Nature communications · 2023Article
- Linking single-cell decisions to collective behaviours in social bacteria.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Interplay of mesoscale physics and agent-like behaviors in the parallel evolution of aggregative multicellularity.EvoDevo · 2020Review
- Allosteric regulation of a prokaryotic small Ras-like GTPase contributes to cell polarity oscillations in bacterial motility.PLoS biology · 2019Article
- Agent-Based Modeling Reveals Possible Mechanisms for Observed Aggregation Cell Behaviors.Biophysical journal · 2018Article
- A gated relaxation oscillator mediated by FrzX controls morphogenetic movements in Myxococcus xanthus.Nature microbiology · 2018Article
- Period-amplitude co-variation in biomolecular oscillators.IET systems biology · 2018Article
- Dissipative structures in biological systems: bistability, oscillations, spatial patterns and waves.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2018Review
- Parameter-robustness analysis for a biochemical oscillator model describing the social-behaviour transition phase of myxobacteria.Proceedings. Mathematical, physical, and engineering sciences · 2018Article
- Colony Expansion of Socially Motile Myxococcus xanthus Cells Is Driven by Growth, Motility, and Exopolysaccharide Production.PLoS computational biology · 2016Article
- Article
- Dual biochemical oscillators may control cellular reversals in Myxococcus xanthus.Biophysical journal · 2014Article
- Describing Myxococcus xanthus aggregation using Ostwald ripening equations for thin liquid films.Scientific reports · 2014Article
- Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos.PLoS biology · 2014Article
- A semi-mechanistic integrated toxicokinetic-toxicodynamic (TK/TD) model for arsenic(III) in hepatocytes.Journal of theoretical biology · 2013Article
- The mechanistic basis of Myxococcus xanthus rippling behavior and its physiological role during predation.PLoS computational biology · 2012Article
- Myxococcus xanthus swarms are driven by growth and regulated by a pacemaker.Journal of bacteriology · 2011Article
- Quantifying aggregation dynamics during Myxococcus xanthus development.Journal of bacteriology · 2011Article
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4 authors.
Funding
Abstract
During development, Myxococcus xanthus cells produce a series of spatial patterns by coordinating their motion through a contact-dependent signal, the C-signal. C-signaling modulates the frequency at which cells reverse their gliding direction. It does this by interacting with the Frz system (a homolog of the Escherichia coli chemosensory system) via a cascade of covalent modifications. Here we show that introducing a negative feedback into this cascade results in oscillatory behavior of the signaling circuit. The model explains several aspects of M. xanthus behavior during development, including the nonrandom distribution of reversal times, and the differences in response of the reversal frequency to both moderate and high levels of C-signaling at different developmental stages. We also propose experiments to test the model.
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