ArticleMolecular biology of the cell2005
Mammalian protein SCP1 forms synaptonemal complex-like structures in the absence of meiotic chromosomes.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 117 citations in OpenAlex.
- Structure and function of the synaptonemal complex.The Journal of cell biology · 2026Review
- The synaptonemal complex: structure, function, and clinical implications†.Biology of reproduction · 2026Article
- Building the synaptonemal complex: Molecular interactions between the axis and the central region.PLoS genetics · 2023Review
- Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.Nature structural & molecular biology · 2023Article
- Unconventional conservation reveals structure-function relationships in the synaptonemal complex.eLife · 2021Article
- Targeting cancer testis antigens in synovial sarcoma.Journal for immunotherapy of cancer · 2021Review
- Synaptonemal Complex dimerization regulates chromosome alignment and crossover patterning in meiosis.PLoS genetics · 2021Article
- Synaptonemal complex proteins modulate the level of genome integrity in cancers.Cancer science · 2021Review
- FAM9B serves as a novel meiosis-related protein localized in meiotic chromosome cores and is associated with human gametogenesis.PloS one · 2021Article
- De novo transcriptome assembly from the gonads of a scleractinian coral, Euphyllia ancora: molecular mechanisms underlying scleractinian gametogenesis.BMC genomics · 2020Article
- SYCP2 Translocation-Mediated Dysregulation and Frameshift Variants Cause Human Male Infertility.American journal of human genetics · 2020Article
- Quantitative basis of meiotic chromosome synapsis analyzed by electron tomography.Scientific reports · 2019Article
- CRL4 regulates recombination and synaptonemal complex aggregation in the Caenorhabditis elegans germline.PLoS genetics · 2019Article
- TH2BS11ph histone mark is enriched in the unsynapsed axes of the XY body and predominantly associates with H3K4me3-containing genomic regions in mammalian spermatocytes.Epigenetics & chromatin · 2019Article
- A molecular model for self-assembly of the synaptonemal complex protein SYCE3.The Journal of biological chemistry · 2019Article
- The E3 ubiquitin ligase Sina regulates the assembly and disassembly of the synaptonemal complex in Drosophila females.PLoS genetics · 2019Article
- Structured illumination microscopy imaging reveals localization of replication protein A between chromosome lateral elements during mammalian meiosis.Experimental & molecular medicine · 2018Article
- Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly.Nature structural & molecular biology · 2018Article
- Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis.The Journal of cell biology · 2017Article
- Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability.International journal of molecular sciences · 2016Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptonemal complexes (SCs) are evolutionary conserved, meiosis-specific structures that play a central role in synapsis of homologous chromosomes, chiasmata distribution, and chromosome segregation. However, it is still for the most part unclear how SCs do assemble during meiotic prophase. Major components of mammalian SCs are the meiosis-specific proteins SCP1, 2, and 3. To investigate the role of SCP1 in SC assembly, we expressed SCP1 in a heterologous system, i.e., in COS-7 cells that normally do not express SC proteins. Notably, under these experimental conditions SCP1 is able to form structures that closely resemble SCs (i.e., polycomplexes). Moreover, we show that mutations that modify the length of the central alpha-helical domain of SCP1 influence the width of polycomplexes. Finally, we demonstrate that deletions of the nonhelical N- or C-termini both affect polycomplex assembly, although in a different manner. We conclude that SCP1 is a primary determinant of SC assembly that plays a key role in synapsis of homologous chromosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.