ReviewThe Biochemical journal2005
Rho GTPases and leucocyte-induced endothelial remodelling.
Review in The Biochemical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 80 citations in OpenAlex.
- A specific role for endothelial EPLIN-isoform-regulated actin dynamics in neutrophil transmigration.Scientific reports · 2025Article
- Article
- Aqueous humor proteomic analysis of acute angle-closure glaucoma with visual field loss.Annals of translational medicine · 2021Article
- RhoGTPase in Vascular Disease.Cells · 2019Review
- How leukocytes trigger opening and sealing of gaps in the endothelial barrier.F1000Research · 2016Review
- Cellular Barriers after Extravasation: Leukocyte Interactions with Polarized Epithelia in the Inflamed Tissue.Mediators of inflammation · 2016Review
- Rho kinase as a target for cerebral vascular disorders.Future medicinal chemistry · 2015Review
- Slit2 prevents neutrophil recruitment and renal ischemia-reperfusion injury.Journal of the American Society of Nephrology : JASN · 2013Article
- MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.Molecular biology of the cell · 2013Article
- Exogenous microparticles of iron oxide bind to activated endothelial cells but, unlike monocytes, do not trigger an endothelial response.Theranostics · 2013Article
- Endothelial membrane reorganization during leukocyte extravasation.Cellular and molecular life sciences : CMLS · 2012Review
- p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation.American journal of physiology. Cell physiology · 2012Article
- On, around, and through: neutrophil-endothelial interactions in innate immunity.Physiology (Bethesda, Md.) · 2011Review
- Organizing the cell cortex: the role of ERM proteins.Nature reviews. Molecular cell biology · 2010Review
- The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.The Journal of cell biology · 2010Article
- Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes.Cellular and molecular bioengineering · 2010Article
- Inhibition of leukocyte adhesion by developmental endothelial locus-1 (del-1).Immune network · 2009Article
- Pharmacologic and chemical adjuvants in tumor virotherapy.Chemical reviews · 2009Review
- Lymphocyte recruitment to the liver: molecular insights into the pathogenesis of liver injury and hepatitis.Toxicology · 2008Review
- Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling.American journal of physiology. Heart and circulatory physiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leucocytes in the bloodstream respond rapidly to inflammatory signals by crossing the blood vessel wall and entering the tissues. This process involves adhesion to, and subsequent transmigration across, the endothelium, mediated by a cascade of interactions between adhesion molecules and stimulation of intracellular signalling pathways in both leucocytes and endothelial cells. This leads to changes in endothelial cell morphology that assist leucocyte extravasation, including endothelial cell contraction, intercellular junction disruption, increased permeability, remodelling of the endothelial apical surface and alterations in vesicle trafficking. Rho GTPases play a central role in many of the endothelial responses to leucocyte interaction. In this review, we discuss recent findings on leucocyte-induced alterations to endothelial cells, and the roles of Rho GTPases in these responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.