ArticleProceedings of the National Academy of Sciences of the United States of America1992
Angiogenin supports endothelial and fibroblast cell adhesion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 103 citations in OpenAlex.
- Spatial distribution and density of fibroblasts determine angiogenic response of endothelial cells.Research square · 2026Article
- Spatial distribution and density of fibroblasts determine angiogenic response of endothelial cells.Microfluidics and nanofluidics · 2026Article
- Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome.Science translational medicine · 2025Article
- Studying sprouting angiogenesis under combination of oxygen gradients and co-culture of fibroblasts using microfluidic cell culture model.Materials today. Bio · 2023Article
- Effects of Recombinant Angiogenin on Collagen Fiber Formation and Angiogenesis in the Dermis of Wistar Rats.Clinical, cosmetic and investigational dermatology · 2021Article
- RNase A Treatment Interferes With Leukocyte Recruitment, Neutrophil Extracellular Trap Formation, and Angiogenesis in Ischemic Muscle Tissue.Frontiers in physiology · 2020Article
- Angiogenin Upregulation Independently Predicts Unfavorable Overall Survival in Proneural Subtype of Glioblastoma.Technology in cancer research & treatment · 2019Article
- Three decades of research on angiogenin: a review and perspective.Acta biochimica et biophysica Sinica · 2016Review
- Angiogenin-loaded fibrin/bone powder composite scaffold for vascularized bone regeneration.Biomaterials research · 2015Article
- Angiogenin mediates androgen-stimulated prostate cancer growth and enables castration resistance.Molecular cancer research : MCR · 2013Article
- Angiogenin expression in human kidneys and Wilms' tumours: relationship with hypoxia and angiogenic factors.International journal of experimental pathology · 2013Article
- Niaspan attenuates the adverse effects of bone marrow stromal cell treatment of stroke in type one diabetic rats.PloS one · 2013Article
- New insights into the role of angiogenin in actin polymerization.International review of cell and molecular biology · 2012Review
- Angiogenin in age-related macular degeneration.Molecular vision · 2011Article
- Angiogenin and SDF-1α serum concentration in patients with systemic sclerosis in relation to clinical status.Archives of medical science : AMS · 2011Article
- Angiogenin enhances cell migration by regulating stress fiber assembly and focal adhesion dynamics.PloS one · 2011Article
- Angiogenin-mediated ribosomal RNA transcription as a molecular target for treatment of head and neck squamous cell carcinoma.Oral oncology · 2010Review
- Tumor angiogenesis: insights and innovations.Journal of oncology · 2010Article
- Angiogenin in sera as an independent prognostic factor in gastric cancer.Journal of cancer research and clinical oncology · 2003Article
- Angiogenin distribution in human term placenta, and expression by cultured trophoblastic cells.Angiogenesis · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When coated on bacteriological plastic at doses greater than or equal to 0.1 microgram/cm2, human and bovine angiogenin support calf pulmonary artery endothelial and Chinese hamster fibroblast cell adhesion and spreading, but do not affect cell adhesion when in solution. The kinetics of endothelial cell attachment to angiogenin are indistinguishable from those in the presence of gelatin. Calcium and/or magnesium ions are critical for cell adhesion or spreading onto angiogenin but protein synthesis and glycoprotein secretion are not necessary. Adhesion to angiogenin is not altered by the addition to the incubation solution of fibronectin, fibrinogen, laminin, collagen I and IV, or vitronectin. The peptide Arg-Gly-Asp-Ser inhibits endothelial cell response to angiogenin whereas the reverse peptide Ser-Asp-Gly-Arg-Gly has no effect. These findings show that angiogenin can serve as an effective substratum for cell adhesion by inducing an interaction similar to but independent from that of other extracellular matrix molecules. Induction of cell adhesion and subsequent migration may be critical steps in the process of angiogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.