ArticleProceedings of the National Academy of Sciences of the United States of America1992
Fte-1, a v-fos transformation effector gene, encodes the mammalian homologue of a yeast gene involved in protein import into mitochondria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 57 citations in OpenAlex.
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- Transcriptional and posttranscriptional silencing of rodent alpha1(I) collagen by a homologous transcriptionally self-silenced transgene.Molecular and cellular biology · 1999Article
- Altered cellular responses by varying expression of a ribosomal protein gene: sequential coordination of enhancement and suppression of ribosomal protein S3a gene expression induces apoptosis.The Journal of cell biology · 1998Article
- Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Identification and characterization of three genes and two pseudogenes on chromosome 13.Human genetics · 1996Article
- The genetics of breast and ovarian cancer.British journal of cancer · 1995Review
- Association of nbl gene expression and glucocorticoid-induced apoptosis in mouse thymus in vivo.Immunology · 1995Article
- Meristem-specific gene expression directed by the promoter of the S-phase-specific gene, cyc07, in transgenic Arabidopsis.Plant molecular biology · 1994Article
- Isolation and characterization of a rice cDNA similar to the S-phase-specific cyc07 gene.Plant molecular biology · 1994Article
- Suppression of anchorage-independent growth after gene transfection.British journal of cancer · 1993Article
- Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
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2 authors at 1 institution in 1 country.
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Abstract
Revertants were isolated from v-fos-transformed rat-1 cells cotransfected with a human cDNA expression library and a selectable marker (pMEX-neo). Molecular analysis of one clone, R2.2, suggested that the revertant phenotype resulted from the disruption of a transformation effector gene by the integration of the pMEX-neo plasmid. Genomic sequences flanking the plasmid integration site were cloned and used as probes in Northern blot analyses. A probe derived from sequences 5' to the integration site hybridized to a unique 1.2-kilobase mRNA and was used to isolate a 0.9-kilobase cDNA clone (fte-1). The open reading frame of the fte-1 cDNA predicts a highly basic protein that shows a remarkable level of similarity with two genes from Saccharomyces cerevisiae. One of these yeast genes contains an unidentified open reading frame and the other, MFT1, is a gene isolated from a yeast mutant that fails to import a fusion protein into mitochondria [Garrett, J. M., Singh, K. K., Vonder Haar, R. A. & Emr, S. D. (1991) Mol. Gen. Genet. 225, 483-491]. Expression of the fte-1 gene was induced approximately 5-fold in v-fos-transformed fibroblasts, but expression was reduced in clone R2.2 and in several independent revertant clones. Transfection of R2.2 cells with fte-1 expression vectors resulted in the reacquisition of a transformed phenotype. These results demonstrate that the mammalian homologue of a gene implicated in protein import into yeast mitochondria is a v-fos transformation effector gene.
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