SynthesisThe Cochrane database of systematic reviews2004
Antifibrinolytic drugs for acute traumatic injury.
Synthesis in The Cochrane database of systematic reviews, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02492087 (Prophylactic Use of Topical Tranexamic Acid to Aid Surgical Haemostasis During Caesarean Sections in Parturients With Moderate to High Risk of Bleeding), which is not on this map. Cited by 17 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prophylactic Use of Topical Tranexamic Acid to Aid Surgical Haemostasis During Caesarean Sections in Parturients With Moderate to High Risk of Bleeding
Who cites it
17 citing papers in PubMed, 7 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Tranexamic acid in the management of traumatic brain injury: a systematic review and meta-analysis with trial sequential analysis.Einstein (Sao Paulo, Brazil) · 2025Pooled it
- Therapeutic efficacy of tranexamic acid on traumatic brain injury: a systematic review and meta-analysis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Pooled it
- Pooled it
- Antifibrinolytic drugs for acute traumatic injury.The Cochrane database of systematic reviews · 2015Pooled it
- The acute management of trauma hemorrhage: a systematic review of randomized controlled trials.Critical care (London, England) · 2011Pooled it
- Haemostatic drugs for traumatic brain injury.The Cochrane database of systematic reviews · 2010Pooled it
- Management of bleeding following major trauma: a European guideline.Critical care (London, England) · 2007Guideline
- Association of Self-Reported Physical Fitness during Late Pregnancy with Birth Outcomes and Oxytocin Administration during Labour-The GESTAFIT Project.International journal of environmental research and public health · 2021Trial
- Article
- Evolution of the role of army transfusion services in the management of trauma patients and battle casualties with massive hemorrhage.Medical journal, Armed Forces India · 2012Review
- Treatment massive haemoptysis in cystic fibrosis with tranexamic acid.Journal of the Royal Society of Medicine · 2011Article
- Posttraumatic massive bleeding: a challenging multidisciplinary task.Internal and emergency medicine · 2010Review
- Temporally and regionally disparate differences in plasmin activity by tranexamic acid.Anesthesia and analgesia · 2010Article
- Thrombelastography and tromboelastometry in assessing coagulopathy in trauma.Scandinavian journal of trauma, resuscitation and emergency medicine · 2009Review
- Blood conservation strategies to reduce the need for red blood cell transfusion in critically ill patients.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2008Article
- An approach to transfusion and hemorrhage in trauma: current perspectives on restrictive transfusion strategies.Canadian journal of surgery. Journal canadien de chirurgie · 2007Review
- Antifibrinolytic agents in traumatic haemorrhage.PLoS medicine · 2005Article
Corrections and comments
- Updated by
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUncontrolled bleeding is an important cause of death in trauma victims. Antifibrinolytic treatment has been shown to reduce blood loss following surgery and may also be effective in reducing blood loss following trauma.
objectivesTo quantify the effect of antifibrinolytic drugs in reducing blood loss, transfusion requirement and mortality after acute traumatic injury. SEARCH STRATEGY: We searched the Cochrane Injuries Group's Specialised Register, the Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, EMBASE, Science Citation Index, National Research Register, Zetoc, SIGLE, Global Health, LILACS, and Current Controlled Trials. SELECTION CRITERIA: We included all randomised controlled trials of antifibrinolytic agents (aprotinin, tranexamic acid [TXA] and epsilon-aminocaproic acid) following acute traumatic injury. DATA COLLECTION AND ANALYSIS: The titles and abstracts identified in the electronic searches were screened by two independent reviewers to identify studies that had the potential to meet the inclusion criteria. The full reports of all such studies were obtained. From the results of the screened electronic searches, bibliographic searches, and contacts with experts, two reviewers independently selected trials meeting the inclusion criteria, with any disagreements resolved by consensus. MAIN
resultsTwo studies met the inclusion criteria. The study by Auer (1979), with 20 randomised patients, provided no useable outcome data. The study by McMichan (1982), with 77 randomised patients, was reported in four separate reports. Outcome data were reported for death, the proportion undergoing surgical intervention and the volume of blood transfused. Because of the small number of randomised participants, the estimates for each of these outcomes were highly imprecise. Data on the proportion undergoing re-operation and the proportion receiving blood transfusion were not reported. REVIEWERS'
conclusionsThere is insufficient evidence from randomised controlled trials of antifibrinolytic agents in trauma to either support or refute a clinically important treatment effect. Further randomised controlled trials of antifibrinolytic agents in trauma are required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.