SynthesisThe Cochrane database of systematic reviews2004
Antibiotic regimens for suspected early neonatal sepsis.
Synthesis in The Cochrane database of systematic reviews, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Antibiotic regimens for early-onset neonatal sepsis.The Cochrane database of systematic reviews · 2021Pooled it
- Feasibility and efficacy of gentamicin for treating neonatal sepsis in community-based settings: a systematic review.World journal of pediatrics : WJP · 2016Pooled it
- Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis.Systematic reviews · 2019Article
- Drugs for the Prevention and Treatment of Sepsis in the Newborn.Clinics in perinatology · 2019Review
- Using machine learning to guide targeted and locally-tailored empiric antibiotic prescribing in a children's hospital in Cambodia.Wellcome open research · 2018Article
- Experimental Neonatal Sepsis Causes Long-Term Cognitive Impairment.Molecular neurobiology · 2016Article
- Article
- Antibiotic Prescriptions and Prophylaxis in Italian Children. Is It Time to Change? Data from the ARPEC Project.PloS one · 2016Article
- High variability in the dosing of commonly used antibiotics revealed by a Europe-wide point prevalence study: implications for research and dissemination.BMC pediatrics · 2015Article
- Essential childbirth and postnatal interventions for improved maternal and neonatal health.Reproductive health · 2014Review
- Results of a two-center, before and after study of piperacillin-tazobactam versus ampicillin and gentamicin as empiric therapy for suspected sepsis at birth in neonates ≤ 1500 g.Journal of perinatology : official journal of the California Perinatal Association · 2013Observational
- Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections.European journal of clinical pharmacology · 2013Article
- Article
- Choice and duration of antimicrobial therapy for neonatal sepsis and meningitis.International journal of pediatrics · 2011Article
- Invasive bacterial infections in neonates and young infants born outside hospital admitted to a rural hospital in Kenya.The Pediatric infectious disease journal · 2010Article
- Clinical parameters predicting failure of empirical antibacterial therapy in early onset neonatal sepsis, identified by classification and regression tree analysis.BMC pediatrics · 2009Article
- Management of the infant at increased risk for sepsis.Paediatrics & child health · 2007Article
- Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks.Antimicrobial agents and chemotherapy · 2007Article
- Empirical antibiotic treatment and the risk of necrotizing enterocolitis and death in very low birth weight neonates.Annals of Saudi medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly acquired infection may cause severe illness or death in the neonatal period. Prompt treatment with antibiotics has shown to reduce mortality. It is not clear which antibiotic regimen is suitable for treatment of presumed early neonatal sepsis.
objectivesTo compare effectiveness and adverse effects of antibiotic regimens for treatment of presumed early neonatal sepsis. SEARCH STRATEGY: The Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 2, 2003), MEDLINE (1966 to August 2003), EMBASE (1980 to September 2003) and ZETOC (1993 to August 2003) databases were searched for possible studies. Pharmaceutical companies were contacted for any unpublished data. SELECTION CRITERIA: Randomised and quasi-randomised controlled studies comparing antibiotic regimens for the treatment of early neonatal sepsis (both monotherapies and combination therapies). DATA COLLECTION AND ANALYSIS: Both reviewers screened abstracts and full reports against the inclusion criteria, appraised the quality of and extracted data from papers. For dichotomous outcomes, treatment effect was expressed as relative risk with 95% confidence interval. Meta-analysis was performed using a fixed effect model. MAIN
resultsTwo small studies had compared monotherapy with combination therapy. There was no significant difference in mortality, treatment failure or bacteriological resistance. REVIEWERS'
conclusionsThere is no evidence from randomised trials to suggest that any antibiotic regimen may be better than any other in the treatment of presumed early neonatal sepsis. More studies are needed to resolve this issue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.