ArticleNucleic acids research1992
Removal of a 3' non-coding sequence is an initial step in degradation of gro alpha mRNA and is regulated by interleukin-1.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 64 citations in OpenAlex.
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- Kinetics and regulation of site-specific endonucleolytic cleavage of human IGF-II mRNAs.Nucleic acids research · 2001Article
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- Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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- A polysomal ribonuclease involved in the destabilization of albumin mRNA is a novel member of the peroxidase gene family.RNA (New York, N.Y.) · 1998Article
- Cleavage properties of an estrogen-regulated polysomal ribonuclease involved in the destabilization of albumin mRNA.Nucleic acids research · 1997Article
- In vivo generation of 3' and 5' truncated species in the process of c-myc mRNA decay.Nucleic acids research · 1996Article
- Degradation of CYC1 mRNA in the yeast Saccharomyces cerevisiae does not require translation.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- mRNA stability in mammalian cells.Microbiological reviews · 1995Review
- Structure and expression of the guinea pig preproenkephalin gene: site-specific cleavage in the 3' untranslated region yields truncated mRNA transcripts in specific brain regions.Molecular and cellular biology · 1995Article
- Specific endonucleolytic cleavages of mouse albumin mRNA and their modulation during liver development.Nucleic acids research · 1995Article
- Long-range RNA interaction of two sequence elements required for endonucleolytic cleavage of human insulin-like growth factor II mRNAs.Molecular and cellular biology · 1995Article
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1 author at 1 institution in 1 country.
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Abstract
I have previously shown that IL-1 regulates the stability of gro alpha mRNA in fibroblasts and that decay is associated with appearance of a smaller species of gro RNA that lacks poly(A). In this study, the relationship between the two species of gro RNA, which migrate at 1.3 and 0.9 kilobases, was characterized. Following withdrawal of IL-1 or addition of IL-1 receptor antagonist, 1.3 kilobase gro alpha mRNA was rapidly degraded and this was associated with increased expression of the 0.9 kilobase RNA. This increase occurred in the presence of actinomycin D, indicating that the 0.9 kilobase gro RNA was a product of a pre-existing transcript. In cells treated with 1 pg/ml IL-1, both species were induced but the 0.9 kilobase RNA appeared later, consistent with a precursor-product relationship. In cells treated with higher doses of IL-1, the 0.9 kilobase RNA was not expressed. Using an RNAase protection assay, the 0.9 kilobase poly(A)-minus gro RNA was found to be derived from gro alpha mRNA by removal of a 130-nucleotide sequence from the 3' non-coding region. This is one of few examples of formation of an mRNA decay intermediate in vivo; it indicates that degradation of the body of gro alpha mRNA is initiated by site-specific nuclease attack. Characterization of the mechanism of gro alpha mRNA degradation is a first step towards identification of the ribonuclease that controls gro alpha mRNA stability.
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