Trial reportMolecular psychiatry2005
A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.
Trial report in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- The Purinergic System as a Target for the Development of Treatments for Bipolar Disorder.CNS drugs · 2022Review
- P2X7 Receptor-Related Genetic Mouse Models - Tools for Translational Research in Psychiatry.Frontiers in neural circuits · 2022Review
- P2X7 Receptor Signaling in Stress and Depression.International journal of molecular sciences · 2019Review
- P2RX7: expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1.PloS one · 2012Article
- Genome-wide searches for bipolar disorder genes.Current psychiatry reports · 2011Article
- Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses.The international journal of neuropsychopharmacology · 2010Article
- Lithium: a key to the genetics of bipolar disorder.Genome medicine · 2009Article
- Candidate region linkage analysis in twins discordant or concordant for depression symptomatology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders.Molecular psychiatry · 2009Article
- Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20.Psychiatric genetics · 2008Article
- Genetics of bipolar disorder.Dialogues in clinical neuroscience · 2008Review
- A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder.Neuromolecular medicine · 2007Article
- A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function.Molecular psychiatry · 2006Article
- Genetics of stress response and stress-related disorders.Dialogues in clinical neuroscience · 2006Review
- Genomewide scan for affective disorder susceptibility Loci in families of a northern Swedish isolated population.American journal of human genetics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous results pointed to a putative gene for susceptibility to bipolar affective disorder located on the chromosomal region 12q23-q24 that segregated in the Saguenay-Lac-St-Jean population of Quebec. We report here results from a second genome-wide scan based on the analysis of 380 polymorphic microsatellite markers. For the purpose of this analysis, an additional 18 families were recruited from the Saguenay-Lac-St-Jean region and pooled to our previous sample to improve its statistical power, giving a total of 394 sampled individuals. This work confirms the presence of a susceptibility locus for affective disorder on chromosome 12q24 with parametric LOD score value of 3.35 at D12S378 when pedigrees were broken into nuclear families and analysed under a recessive segregation model. This result was supported by neighbouring markers and by a LOD score value of 5.05 at D12S378 under model-free analysis. Other regions of lower interest were indicated on chromosomes 2, 5, 7, 9, 10, 17 and 20.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.