ArticleNucleic acids research2004
Characterization of dRFX2, a novel RFX family protein in Drosophila.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1.Cellular and molecular life sciences : CMLS · 2024Article
- Mutation and apoptosis are well-coordinated for protecting against DNA damage-inducing toxicity in Drosophila.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Article
- Characterization of the human RFX transcription factor family by regulatory and target gene analysis.BMC genomics · 2018Article
- Fine tuning of RFX/DAF-19-regulated target gene expression through binding to multiple sites in Caenorhabditis elegans.Nucleic acids research · 2012Article
- Convergent evolution of RFX transcription factors and ciliary genes predated the origin of metazoans.BMC evolutionary biology · 2010Article
- The RFX protein RfxA is an essential regulator of growth and morphogenesis in Penicillium marneffei.Eukaryotic cell · 2010Article
- Distinct isoforms of the RFX transcription factor DAF-19 regulate ciliogenesis and maintenance of synaptic activity.Molecular biology of the cell · 2008Article
- Identification and characterization of novel human tissue-specific RFX transcription factors.BMC evolutionary biology · 2008Article
- Autorepression of rfx1 gene expression: functional conservation from yeast to humans in response to DNA replication arrest.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A transcriptional regulatory element was identified in the region between URE (upstream regulatory element) and DRE (DNA replication-related element) in the Drosophila PCNA gene promoter. This element plays an important role in promoter activity in living flies. A yeast one-hybrid screening using this element as a bait allowed isolation of a cDNA encoding a protein which binds to the element in vitro. Nucleotide sequence analyses revealed that the cDNA encodes a novel protein containing a characteristic DNA-binding domain conserved among the regulatory factor X (RFX) family proteins. We termed this protein Drosophila RFX2 (dRFX2) and this element dRFX2 site. To investigate the function of dRFX2 in vivo, we took the strategy of analyzing the dominant negative effects against the endogenous dRFX2. Transgenic flies were established in which expression of HA-dRFX(202-480) carrying the amino acid sequences from 202 to 480 containing the RFX domain (DNA-binding domain) of dRFX2 was targeted to the cells in the eye imaginal discs. In the eye imaginal disc expressing the HA-dRFX(202-480), the G1-S transition and/or the progression of S phase were/was interrupted, and the ectopic apoptosis was induced, though photoreceptor cells differentiated normally. These results indicate that dRFX2 plays a role in G1-S transition and/or in progression of S phase.
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