Evidence map›Paper›PMID 15494307›Full record

ArticleMolecular cell2004

Global position and recruitment of HATs and HDACs in the yeast genome.

François Robert, Dmitry K Pokholok, Nancy M Hannett, Nicola J Rinaldi, Mark Chandy, Alex Rolfe, Jerry L Workman, David K Gifford, Richard A Young

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 234 citations in OpenAlex.

  1. Article
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  4. Control of Gene Expression via the Yeast CWI Pathway.International journal of molecular sciences · 2022
    Review
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

François RobertWhitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. francois.robert@ircm.qc.ca
Dmitry K Pokholok
Nancy M Hannett
Nicola J Rinaldi
Mark Chandy
Alex Rolfe
Jerry L Workman
David K Gifford
Richard A Young
Whitehead Institute for Biomedical Research · USMassachusetts Institute of Technology · USPennsylvania State University · US

Funding

Transcriptional Regulatory Networks in Living CellsR01HG002668 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI YOUNG, RICHARD · 2003 to 2016
$17.9M
NHGRI NIH HHS R01 HG002668
6 · The paper itself

Abstract

Chromatin regulators play fundamental roles in the regulation of gene expression and chromosome maintenance, but the regions of the genome where most of these regulators function has not been established. We explored the genome-wide occupancy of four different chromatin regulators encoded in Saccharomyces cerevisiae. The results reveal that the histone acetyltransferases Gcn5 and Esa1 are both generally recruited to the promoters of active protein-coding genes. In contrast, the histone deacetylases Hst1 and Rpd3 are recruited to specific sets of genes associated with distinct cellular functions. Our results provide new insights into the association of histone acetyltransferases and histone deacetylases with the yeast genome, and together with previous studies, suggest how these chromatin regulators are recruited to specific regions of the genome.

Indexed as

AcetyltransferasesCell CycleDNA-Binding ProteinsGenomeHistone AcetyltransferasesHistone DeacetylasesNADp300-CBP-Associated FactorProtein KinasesRibosomal ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSirtuin 2SirtuinsSpores, FungalTranscription FactorsAcetyltransferasesDNA-Binding ProteinsEsa1 protein, S cerevisiaeGCN5 protein, S cerevisiaeHistone AcetyltransferasesHistone DeacetylasesHST1 protein, S cerevisiaeNADp300-CBP-Associated FactorProtein KinasesRibosomal ProteinsRPD3 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSirtuin 2SirtuinsTranscription FactorsTryptophan

Identifiers

PMID15494307
PMCPMC3004369
OpenAlexW2098665858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.