Evidence map›Paper›PMID 15494274›Full record

Trial reportJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2004

Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients.

Nelson Lee, K C Allen Chan, David S Hui, Enders K O Ng, Alan Wu, Rossa W K Chiu, Vincent W S Wong, Paul K S Chan, K T Wong, Eric Wong and 4 more

Registry-linked trialOpen access · greenAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04540926 (Utility of Low Doses of Corticosteroids and Cyclosporine Combined With Enoxaparin, in Patients With COVID-19 Pneumonia at the ISSSTE Regional Hospital, Puebla, During the Contingency Period Due to the SARS-Cov2 Pandemic), which is not on this map. Cited by 364 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
364citing papers in PubMed, 15 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04540926 phase1 / phase2unknown statusnot on this mapstarted 2020, after this paper: background citation

Utility of Low Doses of Corticosteroids and Cyclosporine Combined With Enoxaparin, in Patients With COVID-19 Pneumonia at the ISSSTE Regional Hospital, Puebla, During the Contingency Period Due to the SARS-Cov2 Pandemic

TypeinterventionalSponsorInstituto de Seguridad y Servicios Sociales de los Trabajadores del EstadoRan2020 to 2020Enrolled200ConditionsCOVID 19 PneumoniaArmsCyclosporin A
3 · Its place in the literature

Who cites it

364 citing papers in PubMed, 15 syntheses or guidelines pooled it, 674 citations in OpenAlex.

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  12. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020
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  13. Risk Factors for Severe Disease and Efficacy of Treatment in Patients Infected With COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
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  18. Dexamethasone in Hospitalized Patients with Covid-19.The New England journal of medicine · 2021
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304 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Nelson LeeDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, China.
K C Allen Chan
David S Hui
Enders K O Ng
Alan Wu
Rossa W K Chiu
Vincent W S Wong
Paul K S Chan
K T Wong
Eric Wong
C S Cockram
John S Tam
Joseph J Y Sung
Y M Dennis Lo
Chinese University of Hong Kong · CNPrince of Wales Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effect of corticosteroid treatment on the viral load of Severe Acute Respiratory Syndrome (SARS) patients is unknown.

objectiveTo compare the plasma SARS-CoV RNA concentrations in ribavirin-treated patients who received early hydrocortisone therapy with those who received placebo. STUDY

designSerial plasma SARS-CoV RNA concentrations measured in the setting of a prospective, randomized double-blinded, placebo-controlled trial designed to assess the efficacy of "early" (<7 days of illness) hydrocortisone use in previously healthy SARS patients were analyzed. SARS-CoV RNA was quantified using a one-step real-time RT-PCR assay targeting the nucleocapsid gene.

resultsAmong 16 non-ICU cases, SARS-CoV RNA was detected in plasma since day 3-4 after fever onset; viral concentration peaked in the first week, which then rapidly declined in the second week of illness. On days 8, 12, 16, and 20, the cumulative proportion of patients with undetectable virus in plasma was 31%, 69%, 92%, and 100%, respectively. Plasma SARS-CoV RNA concentrations in the second and third week of illness were significantly higher in patients who received initial hydrocortisone treatment (n = 9), as compared to those who received placebo (n = 7)(AUC; Mann-Whitney, P = 0.023). The median time for SARS-CoV to become undetectable in plasma was 12 days (11-20 days) versus 8 days (8-15 days), respectively.

conclusionOur findings suggested "early" corticosteroid treatment was associated with a higher subsequent plasma viral load.

Indexed as

Adrenal Cortex HormonesAdultCoronavirusDouble-Blind MethodHumansProspective StudiesRNA, ViralSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusViral LoadAdrenal Cortex HormonesRNA, Viral

Identifiers

PMID15494274
PMCPMC7108318
OpenAlexW1995121548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.