ArticleJournal of the Association for Research in Otolaryngology : JARO2004
Differences between the negatively activating potassium conductances of Mammalian cochlear and vestibular hair cells.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- The potassium channel subunit KeLife · 2024Article
- The potassium channel subunit KbioRxiv : the preprint server for biology · 2024Article
- Simultaneous recordings from vestibular Type I hair cells and their calyceal afferents in mice.Frontiers in neurology · 2024Article
- KNeuroscience · 2020Article
- Specializations for Fast Signaling in the Amniote Vestibular Inner Ear.Integrative and comparative biology · 2018Review
- An allosteric gating model recapitulates the biophysical properties of IThe Journal of physiology · 2017Article
- KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss.Current opinion in otolaryngology & head and neck surgery · 2008Review
- Temperature enhances exocytosis efficiency at the mouse inner hair cell ribbon synapse.The Journal of physiology · 2007Article
- Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Hair cell ribbon synapses.Cell and tissue research · 2006Review
- M-like K+ currents in type I hair cells and calyx afferent endings of the developing rat utricle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Ca(2+) currents and voltage responses in Type I and Type II hair cells of the chick embryo semicircular canal.Pflugers Archiv : European journal of physiology · 2005Article
- Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Expression and functional phenotype of mouse ERG K+ channels in the inner ear: potential role in K+ regulation in the inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cochlear and type I vestibular hair cells of mammals express negatively activating potassium (K(+)) conductances, called g(K,n) and g(K,L) respectively, which are important in setting the hair cells' resting potentials and input conductances. It has been suggested that the channels underlying both conductances include KCNQ4 subunits from the KCNQ family of K(+) channels. In whole-cell recordings from rat hair cells, we found substantial differences between g(K,n) and g(K,L) in voltage dependence, kinetics, ionic permeability, and stability during whole-cell recording. Relative to g(K,L), g(K,n) had a significantly broader and more negative voltage range of activation and activated with less delay and faster principal time constants over the negative part of the activation range. Deactivation of g(K,n) had an unusual sigmoidal time course, while g(K,L) deactivated with a double-exponential decay. g(K,L), but not g(K,n), had appreciable permeability to Cs(+). Unlike g(K,L), g(K,n)'s properties did not change ("wash out") during the replacement of cytoplasmic solution with pipette solution during ruptured-patch recordings. These differences in the functional expression of g(K,n) and g(K,L) channels suggest that there are substantial differences in their molecular structure as well.
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