ArticleCirculation2004
Evolution of spontaneous atherosclerotic plaque rupture with medical therapy: long-term follow-up with intravascular ultrasound.
Article in Circulation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01200056 (A Prospective, Double-blinded, Randomised Study to Evaluate the Effects of Different Doses of Statin Treatment on Plaque Volume and Composition in Coronary Disease Determined by Virtual Histology Using Intravascular Ultrasound), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Double-blinded, Randomised Study to Evaluate the Effects of Different Doses of Statin Treatment on Plaque Volume and Composition in Coronary Disease Determined by Virtual Histology Using Intravascular Ultrasound
Who cites it
16 citing papers in PubMed, 104 citations in OpenAlex.
- Comparison of ruptured coronary plaques in patients with unstable and stable clinical presentation.Journal of thrombosis and thrombolysis · 2011Trial
- Influence of statin treatment on coronary atherosclerosis visualised using multidetector computed tomography.European radiology · 2010Trial
- Residual risks and evolving atherosclerotic plaques.Molecular and cellular biochemistry · 2023Review
- High-intensity statin treatment is associated with reduced plaque structural stress and remodelling of artery geometry and plaque architecture.European heart journal open · 2021Article
- Thrombus aspiration without stenting in a patient with anterior STEMI: Regression and healing of an unstable plaque assessed by OCT at 24 months of follow-up.Clinical case reports · 2021Article
- Association of D-dimer with Plaque Characteristics and Plasma Biomarkers of Oxidation-Specific Epitopes in Stable Subjects with Coronary Artery Disease.Journal of cardiovascular translational research · 2018Article
- Long-term prognostic impact of the attenuated plaque in patients with acute coronary syndrome.Heart and vessels · 2016Article
- Preventive Percutaneous Coronary Intervention in ST-elevation Myocardial Infarction - The Primacy of Randomised Trials.Interventional cardiology (London, England) · 2015Article
- Tortuosity of coronary bifurcation as a potential local risk factor for atherosclerosis: CFD steady state study based on in vivo dynamic CT measurements.Annals of biomedical engineering · 2015Article
- Coronary-Subclavian Steal: Case Series and Review of the Literature.Clujul medical (1957) · 2015Article
- Assessment of coronary atherosclerosis by IVUS and IVUS-based imaging modalities: progression and regression studies, tissue composition and beyond.The international journal of cardiovascular imaging · 2011Review
- What have we learned about plaque rupture in acute coronary syndromes?Current cardiology reports · 2010Review
- Unexpected coexisting myocardial infarction detected by delayed enhancement MRI.Case reports in medicine · 2009Article
- Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture.American journal of physiology. Heart and circulatory physiology · 2008Article
- Calculation of arterial wall temperature in atherosclerotic arteries: effect of pulsatile flow, arterial geometry, and plaque structure.Biomedical engineering online · 2007Article
- Arterial wall uptake of fluorodeoxyglucose on PET imaging in stable cancer disease patients indicates higher risk for cardiovascular events.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRuptured coronary atheromatous plaque is generally considered to involve a high risk of subsequent clinical events. Few data are available on the natural evolution of non-culprit-lesion ruptured plaque. We therefore used serial intravascular ultrasound (IVUS) to study how such lesions, detected in the context of a first acute coronary syndrome with elevated troponin I levels, develop. METHODS AND
resultsFourteen patients with 28 distinct plaque ruptures (2+/-1 per patient) without significant associated stenosis (minimal lumen cross-sectional area >4 mm2) were included and systematically treated with 40 mg statin and antiplatelet agent (clopidogrel and aspirin for > or =9 months). Mean clinical and IVUS follow-up was 22+/-13 months (median, 22 months). No clinical event related to the lesion under study occurred. On final IVUS examination, half (14 of 28) of the ruptured plaques had healed, and the degree of stenosis tended to diminish (stenosis, 22+/-17% versus 29+/-17% at baseline; P=0.056). No healing-prediction criterion could be identified.
conclusionsNearly 2 years of follow-up found that spontaneous coronary atheromatous plaque rupture without significant stenosis detected on first acute coronary syndrome healed without significant plaque modification in 50% of cases with medical therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.