ArticleBritish journal of pharmacology2004
Lipopolysaccharide fever is initiated via a capsaicin-sensitive mechanism independent of the subtype-1 vanilloid receptor.
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Effects of the TRPV1 antagonist ABT-102 on body temperature in healthy volunteers: pharmacokinetic/ pharmacodynamic analysis of three phase 1 trials.British journal of clinical pharmacology · 2013Trial
- TRP channel activation and cholinergic signaling in insect thermoregulation: evidence from the American cockroach.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Morphological study of the postnatal hippocampal development in the TRPV1 knockout mice.Temperature (Austin, Tex.) · 2023Article
- The neural pathway of the hyperthermic response to antagonists of the transient receptor potential vanilloid-1 channel.Temperature (Austin, Tex.) · 2023Article
- Mechanism underlying the negative inotropic effect in rat left ventricle in hyperthermia: the role of TRPV1.The journal of physiological sciences : JPS · 2020Article
- Neural Mechanisms of Inflammation-Induced Fever.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development.Acta physiologica (Oxford, England) · 2018Article
- Neural pathways involved in infection-induced inflammation: recent insights and clinical implications.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Capsaicin-induced CaAmerican journal of physiology. Lung cellular and molecular physiology · 2017Article
- Effects of afferent and efferent denervation of vagal nerve on endotoxin-induced oxidative stress in rats.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockade.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Modulation of lipopolysaccharide-induced oxidative stress by capsaicin.Inflammopharmacology · 2012Article
- Preservation of acute pain and efferent functions following intrathecal resiniferatoxin-induced analgesia in rats.The journal of pain · 2011Article
- Effects of opioids, cannabinoids, and vanilloids on body temperature.Frontiers in bioscience (Scholar edition) · 2011Review
- The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.The Journal of physiology · 2011Article
- Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Role of the transient receptor potential vanilloid 1 in inflammation and sepsis.Journal of inflammation research · 2011Article
- Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
As pretreatment with intraperitoneal capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel-vanilloid receptor subtype 1 (TRPV-1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats, this phase is thought to depend on the TRPV-1-bearing sensory nerve fibers originating in the abdominal cavity. However, our recent studies suggest that CAP blocks the first phase via a non-neural mechanism. In the present work, we studied whether this mechanism involves the TRPV-1. Adult Long-Evans rats implanted with chronic jugular catheters were used. Pretreatment with CAP (5 mg kg(-1), i.p.) 10 days before administration of LPS (10 microg kg(-1), i.v.) resulted in the loss of the entire first phase and a part of the second phase of LPS fever. Pretreatment with the ultrapotent TRPV-1 agonist resiniferatoxin (RTX; 2, 20, or 200 microg kg(-1), i.p.) 10 days before administration of LPS had no effect on the first and second phases of LPS fever, but it exaggerated the third phase at the highest dose. The latter effect was presumably due to the known ability of high doses of TRPV-1 agonists to cause a loss of warm sensitivity, thus leading to uncontrolled, hyperpyretic responses. Pretreatment with the selective competitive TRPV-1 antagonist capsazepine (N-[2-(4-chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamidem, CPZ; 40 mg kg(-1), i.p.) 90 min before administration of LPS (10 microg kg(-1), i.v.) or CAP (1 mg kg(-1), i.p.) did not affect LPS fever, but blocked the immediate hypothermic response to acute administration of CAP. It is concluded that LPS fever is initiated via a non-neural mechanism, which is CAP-sensitive but RTX- and CPZ-insensitive. The action of CAP on this mechanism is likely TRPV-1-independent. It is speculated that this mechanism may be the production of prostaglandin E(2) by macrophages in LPS-processing organs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.