ArticleBMC genomics2004
GeneLink: a database to facilitate genetic studies of complex traits.
Article in BMC genomics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- dbVOR: a database system for importing pedigree, phenotype and genotype data and exporting selected subsets.BMC bioinformatics · 2015Article
- Mega2: validated data-reformatting for linkage and association analyses.Source code for biology and medicine · 2014Article
- Identification of novel genetic loci for intraocular pressure: a genomewide scan of the Beaver Dam Eye Study.Archives of ophthalmology (Chicago, Ill. : 1960) · 2007Article
- The BiolAD-DB system : an informatics system for clinical and genetic data.Molecular diagnosis & therapy · 2007Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundIn contrast to gene-mapping studies of simple Mendelian disorders, genetic analyses of complex traits are far more challenging, and high quality data management systems are often critical to the success of these projects. To minimize the difficulties inherent in complex trait studies, we have developed GeneLink, a Web-accessible, password-protected Sybase database.
resultsGeneLink is a powerful tool for complex trait mapping, enabling genotypic data to be easily merged with pedigree and extensive phenotypic data. Specifically designed to facilitate large-scale (multi-center) genetic linkage or association studies, GeneLink securely and efficiently handles large amounts of data and provides additional features to facilitate data analysis by existing software packages and quality control. These include the ability to download chromosome-specific data files containing marker data in map order in various formats appropriate for downstream analyses (e.g., GAS and LINKAGE). Furthermore, an unlimited number of phenotypes (either qualitative or quantitative) can be stored and analyzed. Finally, GeneLink generates several quality assurance reports, including genotyping success rates of specified DNA samples or success and heterozygosity rates for specified markers.
conclusionsGeneLink has already proven an invaluable tool for complex trait mapping studies and is discussed primarily in the context of our large, multi-center study of hereditary prostate cancer (HPC). GeneLink is freely available at http://research.nhgri.nih.gov/genelink.
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