ArticleMolecular and cellular biology1992
Transcriptional down-regulation of N-myc expression during B-cell development.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- TargetingFrontiers in oncology · 2020Review
- Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Myc roles in hematopoiesis and leukemia.Genes & cancer · 2010Article
- Transcriptional analysis of the B cell germinal center reaction.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- A novel intron element operates posttranscriptionally To regulate human N-myc expression.Molecular and cellular biology · 1999Article
- Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments.The EMBO journal · 1998Article
- Dietary marine lipids suppress continuous expression of interleukin-1 beta gene transcription.Lipids · 1996Article
- Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.The EMBO journal · 1993Article
- Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses.Molecular and cellular biology · 1993Article
- Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines.The EMBO journal · 1992Article
- Primary central nervous system lymphomas--an update.Journal of cancer research and clinical oncology · 1992Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We have used nuclear run-on and DNase I sensitivity analyses to study the activity of the N-myc genes in cell lines that represent different stages of B-cell development. Both transformed pre-B-cell lines and a nontransformed pre-B-cell clone transcribe the N- and c-myc genes at substantial levels; in the nontransformed clone, transcription of these genes is regulated by the pre-B-cell growth factor interleukin-7. In contrast, transformed cell lines that represent the more mature stages of the B-cell pathway and mitogen-stimulated normal splenic B lymphocytes express the c-myc gene but do not express the N-myc gene at detectable levels. Down-regulation of N-myc expression in these cells occurs at the level of transcriptional initiation. Correspondingly, a set of DNase I-hypersensitive sites present in the 5' region of the N-myc promoter of pre-B-cell lines are absent in B-cell lines. To further elucidate this process, we have constructed fusion cell lines between an N-myc-expressing pre-B-cell line and a nonexpressing myeloma line; the hybrid cell lines transcriptionally down-regulate the pre-B copies of the N-myc gene. Lack of N-myc expression in a number of nonlymphoid cell lines also resulted from lack of N-myc transcription. Together, our findings demonstrate that the down-regulation of N-myc expression in the later stages of B-cell development is mediated primarily at the level of transcriptional initiation. They further show that dominant, trans-acting factors present in more mature B-lineage cell lines act to down-regulate the transcription of N-myc.
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