Trial reportEuropean journal of applied physiology2005
Effects of exercise training and detraining on cutaneous microvascular function in man: the regulatory role of endothelium-dependent dilation in skin vasculature.
Trial report in European journal of applied physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Impacts of Physical Inactivity Models on Endothelial Function: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Effect of exercise training on nitric oxide and nitrate/nitrite (NOx) production: A systematic review and meta-analysis.Frontiers in physiology · 2022Pooled it
- The Effect of Structured Exercise Compared with Education on Neuropathic Signs and Symptoms in People at Risk of Neuropathic Diabetic Foot Ulcers: A Randomized Clinical Trial.Medicina (Kaunas, Lithuania) · 2021Trial
- Effects of supervised exercise training on lower-limb cutaneous microvascular reactivity in adults with venous ulcers.European journal of applied physiology · 2018Trial
- A novel technique for the assessment of preoperative cardiovascular risk: reactive hyperemic response to short-term exercise.BioMed research international · 2013Trial
- Rapid vascular modifications to localized rhythmic handgrip training and detraining: vascular conditioning and deconditioning.European journal of applied physiology · 2010Trial
- Effects of moderate and severe intermittent hypoxia on vascular endothelial function and haemodynamic control in sedentary men.European journal of applied physiology · 2007Trial
- Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus.Diabetologia · 2006Trial
- Laser Doppler mapping of lower limb skin perfusion before and 5 h after exercise in warm conditions.Frontiers in physiology · 2026Article
- Impact of acute and chronic cycling exercise on microvascular reactivity of the upper and lower extremity muscles in young healthy females.Journal of exercise science and fitness · 2025Article
- Single-cell transcriptomic analyses of skin vascular endothelial cells in sedentary and voluntary wheel running young mice.Physiological reports · 2025Article
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- Temporal Skin Temperature as an Indicator of Cardiorespiratory Fitness Assessed with Selected Methods.Biology · 2022Article
- Thermal dysregulation in patients with multiple sclerosis during SARS-CoV-2 infection. The potential therapeutic role of exercise.Multiple sclerosis and related disorders · 2022Review
- Supervised Cycling Training Improves Erythrocyte Rheology in Individuals With Peripheral Arterial Disease.Frontiers in physiology · 2021Article
- Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study.Microcirculation (New York, N.Y. : 1994) · 2020Observational
- Influence of 8-Week Aerobic Training on the Skin Microcirculation in Patients with Ischaemic Heart Disease.Journal of aging research · 2020Article
- The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?Frontiers in physiology · 2019Review
- Acute exhaustive rowing exercise reduces skin microvascular dilator function in young adult rowing athletes.European journal of applied physiology · 2018Article
- Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli.Physiological reviews · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated how exercise training and detraining affect the cutaneous microvascular function and the regulatory role of endothelium-dependent dilation in skin vasculature. Ten healthy sedentary subjects cycled on an ergometer at 50% of maximal oxygen uptake (VO(2max)) for 30 min daily, 5 days a week, for 8 weeks, and then detrained for 8 weeks. Plasma nitric oxide (NO) metabolites (nitrite plus nitrate) were measured by a microplate fluorometer. The cutaneous microvascular perfusion responses to six graded levels of iontophoretically applied 1% acetylcholine (ACh) and 1% sodium nitroprusside (SNP) in the forearm skin were determined by laser Doppler. After training, (1) resting heart rate and blood pressure were reduced, whereas VO(2max), skin blood flow and cutaneous vascular conductance to acute exercise were enhanced; (2) plasma NO metabolite levels and ACh-induced cutaneous perfusion were increased; (3) skin vascular responses to SNP did not change significantly. However, detraining reversed these effects on cutaneous microvascular function and plasma NO metabolite levels. The results suggest that endothelium-dependent dilation in skin vasculature is enhanced by moderate exercise training and reversed to the pretraining state with detraining.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.