ArticleImmunogenetics2004
MICA response to gliadin in intestinal mucosa from celiac patients.
Article in Immunogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 50 citations in OpenAlex.
- MAGI2 Gene Region and Celiac Disease.Frontiers in nutrition · 2019Article
- How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation.Frontiers in immunology · 2017Review
- The Role of T-Cell Subsets in Chronic Inflammation in Celiac Disease and Inflammatory Bowel Disease Patients: More Common Mechanisms or More Differences?Inflammatory intestinal diseases · 2016Review
- Expression analysis in intestinal mucosa reveals complex relations among genes under the association peaks in celiac disease.European journal of human genetics : EJHG · 2015Article
- THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge.European journal of human genetics : EJHG · 2014Article
- Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease.PloS one · 2013Article
- Celiac disease: prevalence, diagnosis, pathogenesis and treatment.World journal of gastroenterology · 2012Review
- Celiac disease in Middle Eastern and North African countries: a new burden?World journal of gastroenterology · 2010Review
- Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study.Arthritis research & therapy · 2009Article
- Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4.Genes and immunity · 2007Article
- The immune recognition of gluten in coeliac disease.Clinical and experimental immunology · 2005Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MHC class I chain-related gene A (MICA), a putative independent susceptibility gene in autoimmune diseases, encodes a surface protein present in epithelial cells that binds to NKG2D, an activating receptor of NK, alphabeta and gammadelta T cells, and could function as a stress-inducible activator of the innate immune response. There is no evidence of a long-term implication of MICA in the celiac autoimmune process. However, it could be that gliadin activation of MICA occurs only during the initial stages of the disease. In order to determine whether MICA is activated in response to gliadin in patients with celiac disease (CD), small intestinal mucosa biopsy samples from ten long-standing celiac patients on a gluten-free diet and from five non-celiac individuals were incubated with and without gliadin for 4 h. Total RNA was purified and MICA, IFNG and NKG2D mRNA were quantified by fluorescent real-time RT-PCR. Expression levels were calculated relative to GAPDH. MICA expression was detected in both patients and controls, but incubation with gliadin induced a strong increase in samples from the treated CD group compared with the non-CD controls (P=0.028), while no differences were observed for IFNG or NKG2D mRNA levels. The gliadin-provoked over-expression of MICA in "normalized" tissues from CD patients suggests a role for this stress-induced activator of the immune response in the early stages of organ-specific autoimmune destruction, probably preceding the onset of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.