ArticleOncogene2004
Regulation of the cyclin A1 protein is associated with its differential subcellular localization in hematopoietic and leukemic cells.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma.British journal of cancer · 2021Article
- Characterization of children with FLT3-ITD acute myeloid leukemia: a report from the AIEOP AML-2002 study group.Leukemia · 2017Article
- Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells.Oncotarget · 2016Article
- Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches.Cell cycle (Georgetown, Tex.) · 2015Article
- Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms.Molecules (Basel, Switzerland) · 2014Review
- CDK1 interacts with RARγ and plays an important role in treatment response of acute myeloid leukemia.Cell cycle (Georgetown, Tex.) · 2013Article
- The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.Cancer cell · 2013Article
- Article
- Cell cycle control in acute myeloid leukemia.American journal of cancer research · 2012Article
- Function of the A-type cyclins during gametogenesis and early embryogenesis.Results and problems in cell differentiation · 2011Review
- The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia.Leukemia · 2009Article
- Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells.Molecular and cellular biochemistry · 2009Article
- Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis.Journal of the National Cancer Institute · 2008Article
- A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer.Oncogene · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
An important role of the cell cycle regulatory protein cyclin A1 in the development of acute myeloid leukemia (AML) was previously demonstrated in a transgenic mouse model. We have now turned our attention to study specific aspects of the activity and subcellular distribution of cyclin A1 using bone marrow samples from normal donors and patients with AML, as well as leukemic cell lines. We show that the localization of cyclin A1 in normal hematopoietic cells is nuclear, whereas in leukemic cells from AML patients and cell lines, it is predominantly cytoplasmic. In leukemic cell lines treated with all-trans retinoic acid (ATRA), cyclin A1 localized to the nucleus. Further, there was a direct interaction between cyclin A1 and cyclin-dependent kinase 1, as well as a major ATRA receptor, RARalpha, in ATRA-treated cells but not in untreated leukemic cells. Our results indicate that the altered intracellular distribution of cyclin A1 in leukemic cells correlates with the status of the leukemic phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.