ArticleGenetics2005
The Dlx gene complement of the leopard shark, Triakis semifasciata, resembles that of mammals: implications for genomic and morphological evolution of jawed vertebrates.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 35 citations in OpenAlex.
- Molecular phylogeny of four homeobox genes from the purple sea star Pisaster ochraceus.Development genes and evolution · 2015Article
- Non-parsimonious evolution of hagfish Dlx genes.BMC evolutionary biology · 2013Article
- Article
- Developmental evidence for serial homology of the vertebrate jaw and gill arch skeleton.Nature communications · 2013Article
- The homology of odontodes in gnathostomes: insights from Dlx gene expression in the dogfish, Scyliorhinus canicula.BMC evolutionary biology · 2011Article
- Annelid Distal-less/Dlx duplications reveal varied post-duplication fates.BMC evolutionary biology · 2011Article
- Article
- A conserved cluster of three PRD-class homeobox genes (homeobrain, rx and orthopedia) in the Cnidaria and Protostomia.EvoDevo · 2010Article
- Functional conservation of a forebrain enhancer from the elephant shark (Callorhinchus milii ) in zebrafish and mice.BMC evolutionary biology · 2010Article
- Gene classification based on amino acid motifs and residues: the DLX (distal-less) test case.PloS one · 2009Article
- Multiple chromosomal rearrangements structured the ancestral vertebrate Hox-bearing protochromosomes.PLoS genetics · 2009Article
- Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters.BMC evolutionary biology · 2008Article
- Expression and function of Dlx genes in the osteoblast lineage.Developmental biology · 2008Article
- Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development.Journal of anatomy · 2005Review
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1 author at 1 institution in 1 country.
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Abstract
Extensive gene duplication is thought to have occurred in the vertebrate lineage after it diverged from cephalochordates and before the divergence of lobe- and ray-finned fishes, but the exact timing remains obscure. This timing was investigated by analysis of the Dlx gene family of a representative cartilaginous fish, the leopard shark, Triakis semifasciata. Dlx genes encode homeodomain transcription factors and are arranged in mammals as three convergently transcribed bigene clusters. Six Dlx genes were cloned from Triakis and shown to be orthologous to single mammalian Dlx genes. At least four of these are arranged in bigene clusters. Phylogenetic analyses of Dlx genes were used to propose an evolutionary scenario in which two genome duplications led to four Dlx bigene clusters in a common ancestor of jawed vertebrates, one of which was lost prior to the diversification of the group. Dlx genes are known to be involved in jaw development, and changes in Dlx gene number are mapped to the same branch of the vertebrate tree as the origin of jaws.
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