ArticleGenetics2005
Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Odz4 upregulates SAN-specific genes to promote differentiation into cardiac pacemaker-like cells.FEBS letters · 2025Article
- Reconstitution of synaptic junctions orchestrated by teneurin-latrophilin complexes.Science (New York, N.Y.) · 2025Article
- The structure of fly Teneurin-m reveals an asymmetric self-assembly that allows expansion into zippers.EMBO reports · 2023Article
- Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands.Nature communications · 2022Article
- An LRR Receptor-Teneurin System Directs Planar Polarity at Compartment Boundaries.Developmental cell · 2019Article
- Teneurins and latrophilins: two giants meet at the synapse.Current opinion in structural biology · 2019Review
- Teneurin Structure: Splice Variants of a Bacterial Toxin Homolog Specifies Synaptic Connections.Frontiers in neuroscience · 2019Review
- Teneurins and Teneurin C-Terminal Associated Peptide (TCAP) in Metabolism: What's Known in Fish?Frontiers in neuroscience · 2019Review
- Latrophilins and Teneurins in Invertebrates: No Love for Each Other?Frontiers in neuroscience · 2019Review
- Discovery of Teneurins.Frontiers in neuroscience · 2019Review
- Nomenclature and Comparative Morphology of the Teneurin/TCAP/ADGRL Protein Families.Frontiers in neuroscience · 2019Review
- Article
- Teneurins: An Integrative Molecular, Functional, and Biomedical Overview of Their Role in Cancer.Frontiers in neuroscience · 2018Review
- Exome Sequencing IdentifiesFrontiers in genetics · 2018Article
- Teneurin-2 presence in rat and human odontoblasts.PloS one · 2017Article
- A study of vertebra number in pigs confirms the association of vertnin and reveals additional QTL.BMC genetics · 2015Article
- Ancient interaction between the teneurin C-terminal associated peptides (TCAP) and latrophilin ligand-receptor coupling: a role in behavior.Frontiers in neuroscience · 2015Review
- Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development.Nature cell biology · 2014Article
- C-terminal region of teneurin-1 co-localizes with the dystroglycan complex in adult mouse testes and regulates testicular size and testosterone production.Histochemistry and cell biology · 2014Article
- Mouse Tenm4 is required for mesoderm induction.BMC developmental biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A mouse homolog of the Drosophila pair-rule gene Odd Oz (Odz4) maps to the critical region of the l7Rn3 locus on mouse chromosome 7. Here we show that Odz4 is an excellent candidate for this allelic series because (1) it spans the entire critical region, (2) the phenotypes correlate with embryonic expression, (3) the complex genetic inheritance of the alleles is consistent with complex transcriptional regulation, and (4) one allele has a mutation in a conserved amino acid. Odz4 uses five alternate promoters that encode both secreted and membrane-bound proteins. Intragenic complementation of the l7Rn3 alleles is consistent with these multiple-protein isoforms. Further, the allelic series shows that Odz4 is required to establish the anterior-posterior axis of the gastrulating mouse embryo and is necessary later for mesoderm-derived tissues such as somites, heart, and skeleton. Sequencing of RT-PCR products from five of the six alleles reveals a nonconservative amino acid change in the l7Rn3(m4) allele. This amino acid is important evolutionarily, as it is conserved to Drosophila. Together, our data indicate that Odz4 is mutated in the l7Rn3 allele series and performs roles in the mouse brain, heart, and embryonic patterning similar to those of its Drosophila counterpart.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.