ArticleGenetics2005
MuDR transposase increases the frequency of meiotic crossovers in the vicinity of a Mu insertion in the maize a1 gene.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The plant early recombinosome: a high security complex to break DNA during meiosis.Plant reproduction · 2024Review
- Crossover-active regions of the wheat genome are distinguished by DMC1, the chromosome axis, H3K27me3, and signatures of adaptation.Genome research · 2021Article
- Structural variation at the maize WUSCHEL1 locus alters stem cell organization in inflorescences.Nature communications · 2021Article
- Heterogeneous transposable elements as silencers, enhancers and targets of meiotic recombination.Chromosoma · 2019Review
- Intragenic Meiotic Crossovers Generate Novel Alleles with Transgressive Expression Levels.Molecular biology and evolution · 2018Article
- Nucleosomes and DNA methylation shape meiotic DSB frequency inGenome research · 2018Article
- High-Resolution Mapping of Crossover Events in the Hexaploid Wheat Genome Suggests a Universal Recombination Mechanism.Genetics · 2017Article
- Amplifying recombination genome-wide and reshaping crossover landscapes in Brassicas.PLoS genetics · 2017Article
- Genetic and epigenetic variation of transposable elements in Arabidopsis.Current opinion in plant biology · 2017Review
- Genome-wide patterns of genetic variation in worldwide Arabidopsis thaliana accessions from the RegMap panel.Nature genetics · 2012Article
- Molecular characterization of a genomic interval with highly uneven recombination distribution on maize chromosome 10 L.Genetica · 2011Article
- Widespread gene conversion in centromere cores.PLoS biology · 2010Article
- Centromeres convert but don't cross.PLoS biology · 2010Article
- Functional viral metagenomics and the next generation of molecular tools.Trends in microbiology · 2010Review
- Role of RAD51 in the repair of MuDR-induced double-strand breaks in maize (Zea mays L.).Genetics · 2008Article
- Article
- Effects of trans-acting genetic modifiers on meiotic recombination across the a1-sh2 interval of maize.Genetics · 2006Article
- Retrotransposon accumulation and satellite amplification mediated by segmental duplication facilitate centromere expansion in rice.Genome research · 2006Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although DNA breaks stimulate mitotic recombination in plants, their effects on meiotic recombination are not known. Recombination across a maize a1 allele containing a nonautonomous Mu transposon was studied in the presence and absence of the MuDR-encoded transposase. Recombinant A1' alleles isolated from a1-mum2/a1::rdt heterozygotes arose via either crossovers (32 CO events) or noncrossovers (8 NCO events). In the presence of MuDR, the rate of COs increased fourfold. This increase is most likely a consequence of the repair of MuDR-induced DNA breaks at the Mu1 insertion in a1-mum2. Hence, this study provides the first in vivo evidence that DNA breaks stimulate meiotic crossovers in plants. The distribution of recombination breakpoints is not affected by the presence of MuDR in that 19 of 24 breakpoints isolated from plants that carried MuDR mapped to a previously defined 377-bp recombination hotspot. This result is consistent with the hypothesis that the DNA breaks that initiate recombination at a1 cluster at its 5' end. Conversion tracts associated with eight NCO events ranged in size from <700 bp to >1600 bp. This study also establishes that MuDR functions during meiosis and that ratios of CO/NCO vary among genes and can be influenced by genetic background.
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