ArticleThe British journal of ophthalmology2004
Neuro-ophthalmological disorders in HIV infected subjects with neurological manifestations.
Article in The British journal of ophthalmology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- Partial pupil-sparing third nerve palsy as a manifestation of cerebral toxoplasmosis in an HIV-positive patient: A case report.American journal of ophthalmology case reports · 2026Article
- Visual evoked and event-related brain potentials in HIV-infected adults: a longitudinal study over 2.5 years.Documenta ophthalmologica. Advances in ophthalmology · 2019Article
- Effects of early HIV infection and combination antiretroviral therapy on intrinsic brain activity: a cross-sectional resting-state fMRI study.Neuropsychiatric disease and treatment · 2019Article
- Longitudinal evaluation of resting-state connectivity, white matter integrity and cortical thickness in stable HIV infection: Preliminary results.The neuroradiology journal · 2017Article
- Pattern- and motion-related visual evoked potentials in HIV-infected adults.Documenta ophthalmologica. Advances in ophthalmology · 2017Article
- Basic and translational neuro-ophthalmology of visually guided saccades: disorders of velocity.Expert review of ophthalmology · 2017Article
- Acute kidney injury and inflammatory immune reconstitution syndrome in mixed genotype (A/E) hepatitis B virus co-infection in HIV-associated lymphoma.International journal of clinical and experimental pathology · 2013Article
- External ophthalmoplegia in human immunodeficiency virus-infected patients receiving antiretroviral therapy.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2012Article
- Reversible progressive supranuclear palsy-like phenotype as an initial manifestation of HIV infection.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Article
- Isolated homonymous hemianopsia due to presumptive cerebral tubercular abscess as the initial manifestation of human immunodeficiency virus infection.Indian journal of ophthalmology · 2012Article
- Human immunodeficiency virus and its effects on the visual system.Infectious disease reports · 2012Review
- Early clinical and subclinical visual evoked potential and Humphrey's visual field defects in cryptococcal meningitis.PloS one · 2012Article
- The eye in sexually transmitted infections: a review of the ocular complications of venereal diseases.International ophthalmology · 2011Review
- The prevalence, clinical features, risk factors and outcome associated with cryptococcal meningitis in HIV positive patients in Kenya.East African medical journal · 2010Article
- Rhesus macaque model of chronic opiate dependence and neuro-AIDS: longitudinal assessment of auditory brainstem responses and visual evoked potentials.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009Article
- Transient loss of consciousness caused by cryptococcal meningitis in an immunocompetent patient: a case report.Cases journal · 2009Article
- HIV-associated lymphoma presenting with painful ophthalmoplegia.Asian journal of neurosurgeryArticle
- Vision recovery in human immunodeficiency virus-infected patients with optic neuropathy treated with highly active antiretroviral therapy: a case series.Indian journal of ophthalmologyArticle
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the frequency and features of neuro-ophthalmological manifestations in neurologically symptomatic HIV infected patients and to assess whether or not the visual evoked potential (VEP) features in these patients differ from those of neurologically asymptomatic HIV infected patients.
methodsNeuro-ophthalmological evaluation was performed in 166 neurologically symptomatic confirmed HIV positive patients, of whom 75 with normal ophthalmological examination were further studied by means of VEPs. The VEPs values were compared to those obtained from 53 other confirmed HIV positive subjects with neither ophthalmological nor neurological manifestations, who served as a comparison group and to the references values of our laboratory.
resultsAn abnormal neuro-ophthalmological examination was noted in 99/166 patients (60%). Eye movement disorders were present in 99 patients (51%). Visual field defects were detected in 39% of the patients. Optic neuropathy was noted in 31%, papilloedema in 27% and ocular motor nerve palsies in 26% of the patients. Toxoplasmosis and cryptococcosis were the most frequent associated pathologies, though in some patients the HIV itself was the presumed cause. VEPs were abnormal in 57% and 42% of patients with and without neurological manifestations, respectively. Compared to asymptomatic patients, symptomatic patients had a significantly increased mean latency; however, both groups had significant increase in mean latency compared to reference values.
conclusionNeuro-ophthalmological manifestations are common in neurologically symptomatic HIV infected patients. Subclinical dysfunction in the visual pathways is a common phenomenon in both HIV infected patients with and without neurological symptoms, but neurologically symptomatic patients seem to have more damage in their visual pathways.
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