ArticleJournal of bacteriology2004
RpoS proteolysis is regulated by a mechanism that does not require the SprE (RssB) response regulator phosphorylation site.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- ROS-sensing transcription factor YchJ regulates RssB-RpoS pathway to protect Salmonella against oxidative attack by macrophages.Nature communications · 2026Article
- RpoS and the bacterial general stress response.Microbiology and molecular biology reviews : MMBR · 2024Review
- A negative feedback loop is critical for recovery of RpoS after stress in Escherichia coli.PLoS genetics · 2024Article
- Structure of phosphorylated-like RssB, the adaptor delivering σThe Journal of biological chemistry · 2023Article
- A negative feedback loop is critical for recovery of RpoS after stress inbioRxiv : the preprint server for biology · 2023Article
- A Broad Continuum of E. coli Traits in Nature Associated with the Trade-off Between Self-preservation and Nutritional Competence.Microbial ecology · 2022Article
- Phospho-dependent signaling during the general stress response by the atypical response regulator and ClpXP adaptor RssB.Protein science : a publication of the Protein Society · 2021Article
- Insight into the RssB-Mediated Recognition and Delivery of σBiomolecules · 2020Article
- Under Elevated c-di-GMP in Escherichia coli, YcgR Alters Flagellar Motor Bias and Speed Sequentially, with Additional Negative Control of the Flagellar Regulon via the Adaptor Protein RssB.Journal of bacteriology · 2019Article
- Control of theEcoSal Plus · 2019Review
- Trouble is coming: Signaling pathways that regulate general stress responses in bacteria.The Journal of biological chemistry · 2019Review
- Structural basis for inhibition of a response regulator of σGenes & development · 2019Article
- ClpP Protease, a Promising Antimicrobial Target.International journal of molecular sciences · 2019Review
- Anti-adaptors use distinct modes of binding to inhibit the RssB-dependent turnover of RpoS (σ(S)) by ClpXP.Frontiers in molecular biosciences · 2015Article
- Regulated proteolysis in bacterial development.FEMS microbiology reviews · 2014Review
- Anti-adaptors provide multiple modes for regulation of the RssB adaptor protein.Genes & development · 2013Article
- Roles of adaptor proteins in regulation of bacterial proteolysis.Current opinion in microbiology · 2013Review
- RpoS proteolysis is controlled directly by ATP levels in Escherichia coli.Genes & development · 2012Article
- The RpoS-mediated general stress response in Escherichia coli.Annual review of microbiology · 2011Review
- Growth phase and (p)ppGpp control of IraD, a regulator of RpoS stability, in Escherichia coli.Journal of bacteriology · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In Escherichia coli the response regulator SprE (RssB) facilitates degradation of the sigma factor RpoS by delivering it to the ClpXP protease. This process is regulated: RpoS is degraded in logarithmic phase but becomes stable upon carbon starvation, resulting in its accumulation. Because SprE contains a CheY domain with a conserved phosphorylation site (D58), the prevailing model posits that this control is mediated by phosphorylation. To test this model, we mutated the conserved response regulator phosphorylation site (D58A) of the chromosomal allele of sprE and monitored RpoS levels in response to carbon starvation. Though phosphorylation contributed to the SprE basal activity, we found that RpoS proteolysis was still regulated upon carbon starvation. Furthermore, our results indicate that phosphorylation of wild-type SprE occurs by a mechanism that is independent of acetyl phosphate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.