ArticleJournal of neurology, neurosurgery, and psychiatry2004
Inappropriate emergency management of status epilepticus in children contributes to need for intensive care.
Article in Journal of neurology, neurosurgery, and psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.
- Autonomic dysfunction and sudden death in patients with Rett syndrome: a systematic reviewJournal of psychiatry & neuroscience : JPN · 2020Pooled it
- Trial
- Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial.Epilepsia · 2021Trial
- Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT.Health technology assessment (Winchester, England) · 2020Trial
- Trial
- Trial
- Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions.British journal of clinical pharmacology · 2008Trial
- Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study.The Lancet. Neurology · 2008Trial
- Article
- Treatment outcome and its predictors among patients with status epilepticus in Africa: A systematic review and meta-analysis.Exploratory research in clinical and social pharmacy · 2026Review
- Intubation in children presenting with seizures to a pediatric emergency department in a safety net hospital.Frontiers in pediatrics · 2026Article
- Management of Status Epilepticus in Children before and after Implementation of a Treatment Algorithm.The Canadian journal of hospital pharmacy · 2026Article
- A Quality Improvement Initiative to Reduce Underdosing of Rectal Diazepam as Home Seizure Rescue Medication After Hospitalization.Neurology. Clinical practice · 2025Article
- Compliance with status epilepticus management protocol and effect on clinical outcomes in children with status epilepticus.European journal of hospital pharmacy : science and practice · 2023Observational
- Optimal Management of Status Epilepticus in Children in the Emergency Setting: A Review of Recent Advances.Open access emergency medicine : OAEM · 2022Review
- The Efficacy and Use of a Pocket Card Algorithm in Status Epilepticus Treatment.Neurology. Clinical practice · 2021Article
- Article
- Hemispheric Cerebral Oximetry Monitoring During Pediatric Seizure Activity in a Pediatric Emergency Department.Pediatric emergency care · 2020Observational
- Evaluation of adherence to pediatric status epilepticus management guidelines in Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2020Article
- Pharmacotherapy for Pediatric Convulsive Status Epilepticus.CNS drugs · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo characterise the clinical features, emergency pre-paediatric intensive care (PIC) treatment, and course of status epilepticus (SE) in children admitted to PIC. This may provide insight into reasons for admission to PIC and provide a framework for the development of strategies that decrease the requirement for intensive care.
designCross sectional, retrospective study.
settingA tertiary paediatric institution's intensive care unit.
participantsThe admission database and all discharge summaries of each admission to a tertiary paediatric institution's PIC over a three year period were searched for children aged between 29 days and 15 years with a diagnosis of SE or related diagnoses. The case notes of potential cases of SE were systematically reviewed, and clinical and demographic data extracted using a standard data collection form.
resultsMost children with SE admitted to PIC are aged less than 5 years, male to female ratio 1:1, and most (77%) will have had no previous episodes of SE. Prolonged febrile convulsions, SE related to central nervous system infection, and SE associated with epilepsy occur in similar proportions. Contrary to the Advanced Paediatric Life Support guidelines many children admitted to PIC for SE receive over two doses, or inadequate doses, of benzodiazepine. There is a risk of respiratory depression following administration of over two doses of benzodiazepine (chi2 = 3.4, p = 0.066). Children with SE admitted to PIC who had prehospital emergency treatment are more likely to receive over two doses of benzodiazepines (chi2 = 11.5, p = 0.001), and to subsequently develop respiratory insufficiency (chi2 = 6.2, p = 0.01). Mortality is low. Further study is required to determine the morbidity associated with SE in childhood requiring intensive care.
conclusionsAs the risk of respiratory depression is greater with more than two doses of benzodiazepines, clinicians should not disregard prehospital treatment of SE. As pre-PIC treatment of SE is inadequate in many cases, appropriate audit and modifications of standard guidelines are required.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.