ArticleGenome research2004
From ORFeome to biology: a functional genomics pipeline.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes.Viruses · 2020Review
- Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy.Autophagy · 2020Article
- Hallmarks of therapeutic management of the cystic fibrosis functional landscape.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2015Review
- Recent advances on host plants and expression cassettes' structure and function in plant molecular pharming.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2014Review
- A high-throughput platform for lentiviral overexpression screening of the human ORFeome.PloS one · 2011Article
- Automated production of recombinant human proteins as resource for proteome research.Proteome science · 2008Article
- Differential regulation of the two transcriptional activation domains of the coiled-coil coactivator CoCoA by sumoylation.BMC molecular biology · 2008Article
- New gateways to discovery.Plant physiology · 2007Review
- The full-ORF clone resource of the German cDNA Consortium.BMC genomics · 2007Article
- The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis.Molecular & cellular proteomics : MCP · 2007Article
- Tetracycline regulated systems in functional oncogenomics.Translational oncogenomics · 2007Article
- Role of the N-terminal activation domain of the coiled-coil coactivator in mediating transcriptional activation by beta-catenin.Molecular endocrinology (Baltimore, Md.) · 2006Article
- The LIFEdb database in 2006.Nucleic acids research · 2006Article
- Statistical methods and software for the analysis of highthroughput reverse genetic assays using flow cytometry readouts.Genome biology · 2006Article
- Downstream signaling mechanism of the C-terminal activation domain of transcriptional coactivator CoCoA.Nucleic acids research · 2006Article
- Refining protein subcellular localization.PLoS computational biology · 2005Article
- Improved tagging strategy for protein identification in mammalian cells.BMC genomics · 2005Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As several model genomes have been sequenced, the elucidation of protein function is the next challenge toward the understanding of biological processes in health and disease. We have generated a human ORFeome resource and established a functional genomics and proteomics analysis pipeline to address the major topics in the post-genome-sequencing era: the identification of human genes and splice forms, and the determination of protein localization, activity, and interaction. Combined with the understanding of when and where gene products are expressed in normal and diseased conditions, we create information that is essential for understanding the interplay of genes and proteins in the complex biological network. We have implemented bioinformatics tools and databases that are suitable to store, analyze, and integrate the different types of data from high-throughput experiments and to include further annotation that is based on external information. All information is presented in a Web database (http://www.dkfz.de/LIFEdb). It is exploited for the identification of disease-relevant genes and proteins for diagnosis and therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.