ArticleBiophysical journal2005
A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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78 citing papers in PubMed, 213 citations in OpenAlex.
- Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions.Biophysical journal · 2025Article
- Dynamic cellular responses to gravitational forces: Exploring the impact on white blood cell(s).Biomicrofluidics · 2024Article
- Circulating cellular clusters are associated with thrombotic complications and clinical outcomes in COVID-19.iScience · 2023Article
- Influence of the vessel wall geometry on the wall-induced migration of red blood cells.PLoS computational biology · 2023Article
- In silico and in vitro study of the adhesion dynamics of erythrophagocytosis in sickle cell disease.Biophysical journal · 2023Article
- Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes.Biophysical journal · 2022Article
- The role of adhesive receptor patterns on cell transport in complex microvessels.Biomechanics and modeling in mechanobiology · 2022Article
- Alpha-mangostin dephosphorylates ERM to induce adhesion and decrease surface stiffness in KG-1 cells.Human cell · 2022Article
- Mechanical stiffness softening and cell adhesion are coordinately regulated by ERM dephosphorylation in KG-1 cells.Human cell · 2021Article
- Gelatin Promotes Cell Retention Within Decellularized Heart Extracellular Matrix Vasculature and Parenchyma.Cellular and molecular bioengineering · 2020Article
- Investigating the Interaction Between Circulating Tumor Cells and Local HydrodynamicsCellular and molecular bioengineering · 2020Article
- An Active Biomechanical Model of Cell Adhesion Actuated by Intracellular Tensioning-Taxis.Biophysical journal · 2020Article
- Localization of Rolling and Firm-Adhesive Interactions Between Circulating Tumor Cells and the Microvasculature Wall.Cellular and molecular bioengineering · 2020Article
- A stochastic model for cell adhesion to the vascular wall.Journal of mathematical biology · 2019Article
- Quantifying Shear-Induced Deformation and Detachment of Individual Adherent Sickle Red Blood Cells.Biophysical journal · 2019Article
- Role of deformable cancer cells on wall shear stress-associated-VEGF secretion by endothelium in microvasculature.PloS one · 2019Article
- Quantifying Platelet Margination in Diabetic Blood Flow.Biophysical journal · 2018Article
- Computational study of cell adhesion and rolling in flow channel by meshfree method.Computer methods in biomechanics and biomedical engineering · 2017Article
- Mechanocellular models of epithelial morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Rolling Adhesion of Schizont Stage Malaria-Infected Red Blood Cells in Shear Flow.Biophysical journal · 2017Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukocyte recruitment to sites of inflammation is initiated by their tethering and rolling on the activated endothelium under flow. Even though the fast kinetics and high tensile strength of selectin-ligand bonds are primarily responsible for leukocyte rolling, experimental evidence suggests that cellular properties such as cell deformability and microvillus elasticity actively modulate leukocyte rolling behavior. Previous theoretical models either assumed cells as rigid spheres or were limited to two-dimensional representations of deformable cells with deterministic receptor-ligand kinetics, thereby failing to accurately predict leukocyte rolling. We therefore developed a three-dimensional computational model based on the immersed boundary method to predict receptor-mediated rolling of deformable cells in shear flow coupled to a Monte Carlo method simulating the stochastic receptor-ligand interactions. Our model predicts for the first time that the rolling of more compliant cells is relatively smoother and slower compared to cells with stiffer membranes, due to increased cell-substrate contact area. At the molecular level, we show that the average number of bonds per cell as well as per single microvillus decreases with increasing membrane stiffness. Moreover, the average bond lifetime decreases with increasing shear rate and with increasing membrane stiffness, due to higher hydrodynamic force experienced by the cell. Taken together, our model captures the effect of cellular properties on the coupling between hydrodynamic and receptor-ligand bond forces, and successfully explains the stable leukocyte rolling at a wide range of shear rates over that of rigid microspheres.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.