ArticleJournal of neurophysiology2004
Dopamine receptor activation can reduce voltage-gated Na+ current by modulating both entry into and recovery from inactivation.
Article in Journal of neurophysiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 42 citations in OpenAlex.
- Activation of Dopamine D1 Receptors at the Axon Initial Segment-Like Process of Retinal AII Amacrine Cells Modulates Action Potential Firing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Calcium/calmodulin-dependent protein kinase II associates with the KFrontiers in neuroanatomy · 2022Article
- Dopamine D2 Receptor-Mediated Modulation of Rat Retinal Ganglion Cell Excitability.Neuroscience bulletin · 2020Article
- Illuminating and Sniffing Out the Neuromodulatory Roles of Dopamine in the Retina and Olfactory Bulb.Frontiers in cellular neuroscience · 2020Review
- Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells.Frontiers in cellular neuroscience · 2020Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Autophosphorylated CaMKII Facilitates Spike Propagation in Rat Optic Nerve.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina.Scientific reports · 2017Article
- M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Multiple cone pathways are involved in photic regulation of retinal dopamine.Scientific reports · 2016Article
- Parallel Inhibition of Dopamine Amacrine Cells and Intrinsically Photosensitive Retinal Ganglion Cells in a Non-Image-Forming Visual Circuit of the Mouse Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Inhibition of tetrodotoxin-resistant sodium current in dorsal root ganglia neurons mediated by D1/D5 dopamine receptors.Molecular pain · 2013Article
- Recurrent axon collaterals of intrinsically photosensitive retinal ganglion cells.Visual neuroscience · 2013Article
- Learning intrinsic excitability in medium spiny neurons.F1000Research · 2013Article
- Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells.The Journal of comparative neurology · 2012Article
- Dopaminergic modulation of ganglion-cell photoreceptors in rat.The European journal of neuroscience · 2012Article
- The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Melanopsin and inner retinal photoreception.Cellular and molecular life sciences : CMLS · 2010Review
- Inhibition of adult rat retinal ganglion cells by D1-type dopamine receptor activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We tested whether dopamine receptor activation modulates the voltage-gated Na+ current of goldfish retinal ganglion cells, using a fast voltage-clamp amplifier, perforated-patch whole cell mode, and a physiological extracellular Na+ concentration. As found in other cells, activators of D1-type dopamine receptors and of protein kinase A reduced the amplitude of current activated by depolarizations from resting potential without altering the current kinetics or activation range. However, D1-type dopamine receptor activation also accelerated the rate of entry into inactivation during subthreshold depolarizations and slowed the rate of recovery from inactivation after single, brief depolarizations. Our results provide the first evidence in any preparation that D1-type receptor activation can produce both of these latter effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.