ArticleProceedings of the National Academy of Sciences of the United States of America2004
Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Epigenetic regulation of humoral immunity: molecular mechanisms, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Review
- 53BP1 Contributes toJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- The AID-induced DNA damage response in chromatin.Molecular cell · 2013Review
- Three-dimensional architecture of the IgH locus facilitates class switch recombination.Annals of the New York Academy of Sciences · 2012Article
- AID targeting is dependent on RNA polymerase II pausing.Seminars in immunology · 2012Review
- Mice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations.Molecular immunology · 2012Article
- Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination.Biochimica et biophysica acta · 2012Review
- Article
- High resolution analysis of the chromatin landscape of the IgE switch region in human B cells.PloS one · 2011Article
- AID and somatic hypermutation.Advances in immunology · 2010Review
- Binding of LBP-1a to specific immunoglobulin switch regions in vivo correlates with specific repression of class switch recombination.European journal of immunology · 2009Article
- H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Chromatin structure regulates gene conversion.PLoS biology · 2007Article
- Nucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene.Molecular immunology · 2007Article
- Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.The Journal of experimental medicine · 2007Article
- NF-kappa B binds to the immunoglobulin S gamma 3 region in vivo during class switch recombination.European journal of immunology · 2006Article
- AID-dependent histone acetylation is detected in immunoglobulin S regions.The Journal of experimental medicine · 2006Article
- Antibody diversification: mutational mechanisms and oncogenesis.Immunologic research · 2006Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Class switch recombination (CSR) allows B cells to make effective protective antibodies. CSR involves the replacement of the mu constant region with one of the downstream constant regions by recombination between the donor and recipient switch (S) regions. Although histone H3 hyperacetylation in recipient S regions was recently reported to coincide with CSR, the relative histone H3 and H4 acetylation status of the donor and recipient S regions and the relationship between the generation of mutations and histone hyperacetylation in S regions have not been addressed. Here we report that histone H3 and H4 were constitutively hyperacetylated in the donor Smu region before and after different mitogen and cytokine treatments. We observed an increased frequency of mutations in hyperacetylated Sgamma DNA segments immunoprecipitated with anti-acetyl histone antibodies. Furthermore, time course experiments revealed that the pattern of association of RNA polymerase II with S regions was much like that of H3 hyperacetylation but not always like that of H4 hyperacetylation. Collectively, our data suggest that H3 and H4 histone hyperacetylation in different S regions is regulated differently, that RNA polymerase II distribution and H3 hyperacetylation reflect the transcriptional activity of a given S region, and that transcription, hyperacetylation, and mutation are not sufficient to guarantee CSR. These findings support the notion that there are additional modifications and/or factors involved in the complex process of CSR.
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