ArticleThe Journal of physiology2004
Chronic decentralization potentiates neurovascular transmission in the isolated rat tail artery, mimicking the effects of spinal transection.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Spinal cord injury alters purinergic neurotransmission to mesenteric arteries in rats.American journal of physiology. Heart and circulatory physiology · 2020Article
- Relation between resting sympathetic outflow and vasoconstrictor responses to sympathetic nerve bursts: sex differences in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Chronic, complete cervicalJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Physical Exercise-Induced Cardiovascular and Thermoregulatory Adjustments Are Impaired in Rats Subjected to Cutaneous Artery Denervation.Frontiers in physiology · 2018Article
- Propofol injection combined with bone marrow mesenchymal stem cell transplantation better improves electrophysiological function in the hindlimb of rats with spinal cord injury than monotherapy.Neural regeneration research · 2015Article
- Structural remodeling of the heart and its premotor cardioinhibitory vagal neurons following T(5) spinal cord transection.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Spinal cord injury increases the reactivity of rat tail artery to angiotensin II.Frontiers in neuroscience · 2014Article
- Article
- Removal of half the sympathetic innervation does not reduce vasoconstrictor responses in rat tail artery.The Journal of physiology · 2013Article
- Dynamic interaction between the heart and its sympathetic innervation following T5 spinal cord transection.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Somatosympathetic Vasoconstrictor Reflexes in Human Spinal Cord Injury: Responses to Innocuous and Noxious Sensory Stimulation below Lesion.Frontiers in physiology · 2012Article
- Structural neuroplasticity following T5 spinal cord transection: increased cardiac sympathetic innervation density and SPN arborization.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Transient supersensitivity to alpha-adrenoceptor agonists, and distinct hyper-reactivity to vasopressin and angiotensin II after denervation of rat tail artery.British journal of pharmacology · 2010Article
- Diversity of sympathetic vasoconstrictor pathways and their plasticity after spinal cord injury.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2007Review
- Regulation of sympathetic nerve traffic to skeletal muscle in resting humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2006Review
- Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans.The Journal of physiology · 2006Article
- Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.British journal of pharmacology · 2005Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord transection produces a marked increase in the response of the isolated rat tail artery to sympathetic nerve stimulation, possibly as a result of a decrease in ongoing sympathetic activity. We have tested the effects of removing ongoing nerve activity on neurovascular transmission by cutting the preganglionic input to postganglionic neurones supplying the tail artery (decentralization). Isometric contractions to nerve stimulation were compared between decentralized arteries and those from age-matched and sham-operated controls. Nerve-evoked responses of decentralized arteries were much larger than those of control arteries at 2 and 7 weeks post operatively. The extent of blockade of nerve-evoked contraction by alpha-adrenoceptor antagonists prazosin (10 nM) or idazoxan (0.1 microM) was reduced. Decentralized arteries were transiently supersensitive to the alpha1-adrenoceptor agonist phenylephrine and the alpha2-adrenoceptor agonist clonidine; the unchanged sensitivity to methoxamine and phenylephrine after 2 weeks indicated no effect on the neuronal noradrenaline uptake transporter. Decentralized arteries were hypersensitive to alpha,beta methylene-ATP, but the P2-purinoceptor antagonist suramin (0.1 mM) did not reduce nerve-evoked contractions. Enlarged responses to 60 mM K+ after both 2 and 7 weeks were correlated with the response of the arteries to nerve stimulation, suggesting that increased postjunctional reactivity contributes to the enhanced contraction. Comparison between data from decentralized arteries and our previous data from spinalized animals showed that the two lesions similarly potentiate nerve-evoked contractions and have similar but not identical postjunctional effects. The enhanced vascular responses following a reduction in tonic nerve activity may contribute to the hypertensive episodes of autonomic dysreflexia in spinally injured patients.
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