ArticleAnnals of the rheumatic diseases2005
A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French population.
Article in Annals of the rheumatic diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: a meta-analysis.Clinical rheumatology · 2016Pooled it
- Association of STAT4 polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis.Molecular biology reports · 2010Pooled it
- The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets.Arthritis research & therapy · 2009Pooled it
- PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis.Rheumatology international · 2007Pooled it
- Novel functional polymorphism onSaudi journal of biological sciences · 2022Article
- PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets.Nature reviews. Rheumatology · 2020Review
- Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis.Arthritis research & therapy · 2016Article
- Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.BMC musculoskeletal disorders · 2016Article
- Article
- Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.Molecular medicine (Cambridge, Mass.) · 2014Article
- Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis.Journal of genetics · 2014Review
- PADI4 haplotypes in association with RA Mexican patients, a new prospect for antigen modulation.Clinical & developmental immunology · 2013Article
- PADI2 is significantly associated with rheumatoid arthritis.PloS one · 2013Article
- Article
- The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population.Rheumatology international · 2011Article
- Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population.Genes and immunity · 2011Article
- Serum anti-modified citrullinated vimentin antibody concentration is associated with liver fibrosis in patients with chronic hepatitis.Hepatic medicine : evidence and research · 2011Article
- Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis--a genome-wide study combined with immunological analyses.PloS one · 2011Article
- Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.Arthritis research & therapy · 2010Article
- Diagnostic utility of anti-cyclic citrullinated peptide antibodies for rheumatoid arthritis in patients with active lung tuberculosis.Clinical rheumatology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutoantibodies to citrullinated proteins (ACPA) are considered a specific marker for rheumatoid arthritis. Peptidylarginine deiminase (PAD) is the enzyme that converts arginyl into citrullyl residues; different isoforms of the enzyme are expressed in mammals. It has been suggested that the PADI4 gene may contribute to genetic susceptibility to rheumatoid arthritis, but conflicting results have been obtained in different populations.
objectiveTo test the hypothesis that the PADI4 gene may confer susceptibility to rheumatoid arthritis in a white French population, using powerful and highly reliable family based association tests.
methodsDNA samples were analysed from 100 families where one member was affected by rheumatoid arthritis and both parents were available for sampling. Five single nucleotide polymorphisms, located within the PADI4 gene and in its close proximity, were genotyped by restriction fragment length polymorphism, and haplotypes were constructed. The analysis involved use of the transmission disequilibrium test and genotype relative risk. ACPA were detected by ELISA on cyclic citrullinated peptides and on human deiminated fibrinogen.
resultsNo single SNP or haplotype was associated with the disease, or was preferentially transmitted. No association was found when patients were partitioned according to ACPA positivity.
conclusionsNo PADI4 haplotype is associated with rheumatoid arthritis in a white French population. The role of genes encoding the other PAD isoforms, or modulating tissue expression or enzyme activity, remains to be elucidated.
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