Lessons from the withdrawal of rofecoxib.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis.Journal of the Royal Society of Medicine · 2006
   Pooled it
2. Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials.BMJ (Clinical research ed.) · 2004
   Pooled it
3. The effects of hip muscle strengthening on knee load, pain, and function in people with knee osteoarthritis: a protocol for a randomised, single-blind controlled trial.BMC musculoskeletal disorders · 2007
   Trial
4. Effects of laterally wedged insoles on symptoms and disease progression in medial knee osteoarthritis: a protocol for a randomised, double-blind, placebo controlled trial.BMC musculoskeletal disorders · 2007
   Trial
5. Cyclooxygenase-2 selective inhibitors in cancer prevention and therapy: inflammopharmacological basis and translational prospects.Medical oncology (Northwood, London, England) · 2026
   Review
6. US postmarketed drug removals: Analysis of discontinued and withdrawn drugs.The Journal of pharmacology and experimental therapeutics · 2026
   Review
7. Integrative GC-MS, FT-IR, and Molecular Docking Analysis ofFood science & nutrition · 2026
   Article
8. A Chrono-Prolific Controlled Release Tripartite Tablet: Case Study of Paracetamol, Diclofenac Sodium and Esomeprazole Magnesium Trihydrate.AAPS PharmSciTech · 2025
   Article
9. Overall compilation of adverse effects of non-steroidal anti-inflammatory drugs: a hypothesis-free systematic investigation using a nationwide cohort study.Frontiers in pharmacology · 2025
   Article
10. The need for "gentle medicine" in a post Covid-19 world.Medicine, health care, and philosophy · 2021
    Review
11. Gaseous Mediators as a Key Molecular Targets for the Development of Gastrointestinal-Safe Anti-Inflammatory Pharmacology.Frontiers in pharmacology · 2021
    Review
12. Pharmacology-informed prediction of the risk posed to fish by mixtures of non-steroidal anti-inflammatory drugs (NSAIDs) in the environment.Environment international · 2021
    Article
13. Pharmacovigilance in developing countries (part I): importance and challenges.International journal of clinical pharmacy · 2018
    Article
14. Raging the War Against Inflammation With Natural Products.Frontiers in pharmacology · 2018
    Review
15. NSAID hypersensitivity - recommendations for diagnostic work up and patient management.Allergo journal international · 2018
    Review
16. Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs.International journal of inflammation · 2017
    Review
17. Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.ALTEX · 2016
    Review
18. Illicit Internet availability of drugs subject to recall and patient safety consequences.International journal of clinical pharmacy · 2015
    Article
19. Correlation between Drug Market Withdrawals and Socioeconomic, Health, and Welfare Indicators Worldwide.Journal of Korean medical science · 2015
    Article
20. Delays in the post-marketing withdrawal of drugs to which deaths have been attributed: a systematic investigation and analysis.BMC medicine · 2015
    Article

Corrections and comments

• Commented on by
  Lessons from the withdrawal of rofecoxib: France has policy for overall assessment of public health impact of new drugs.2004
• Commented on by
  Lessons from the withdrawal of rofecoxib: Observational studies should not be forgotten.2004
• Commented on by
  Sentinel systems are needed for long term adverse drug reactions.2005

Authors and funding

4 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as