ArticleMolecular and cellular biology2004
Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-mediated activation of STA1 expression.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Fungal biofilm formation and its regulatory mechanism.Heliyon · 2024Review
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- Ploidy evolution in a wild yeast is linked to an interaction between cell type and metabolism.PLoS biology · 2023Article
- FLO8 deletion leads to decreased adhesion and virulence with downregulated expression of EPA1, EPA6, and EPA7 in Candida glabrata.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- A re-evaluation of diastatic Saccharomyces cerevisiae strains and their role in brewing.Applied microbiology and biotechnology · 2020Review
- Deciphering eukaryotic gene-regulatory logic with 100 million random promoters.Nature biotechnology · 2020Article
- A deletion in the STA1 promoter determines maltotriose and starch utilization in STA1+ Saccharomyces cerevisiae strains.Applied microbiology and biotechnology · 2019Article
- Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross.Nature communications · 2016Article
- Evidence for a Pneumocystis carinii Flo8-like transcription factor: insights into organism adhesion.Medical microbiology and immunology · 2016Article
- IRES-dependent translated genes in fungi: computational prediction, phylogenetic conservation and functional association.BMC genomics · 2015Article
- Molecular mechanism of flocculation self-recognition in yeast and its role in mating and survival.mBio · 2015Article
- Transcription Factor SomA Is Required for Adhesion, Development and Virulence of the Human Pathogen Aspergillus fumigatus.PLoS pathogens · 2015Article
- Genetic interactions involving five or more genes contribute to a complex trait in yeast.PLoS genetics · 2014Article
- TEAK: topology enrichment analysis framework for detecting activated biological subpathways.Nucleic acids research · 2013Article
- Chromatin modulation at the FLO11 promoter of Saccharomyces cerevisiae by HDAC and Swi/Snf complexes.Genetics · 2012Article
- A profile of differentially abundant proteins at the yeast cell periphery during pseudohyphal growth.The Journal of biological chemistry · 2010Article
- Mss11, a transcriptional activator, is required for hyphal development in Candida albicans.Eukaryotic cell · 2009Article
- Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase.Cell division · 2009Article
- Modelling transcriptional regulation with a mixture of factor analyzers and variational Bayesian expectation maximization.EURASIP journal on bioinformatics & systems biology · 2009Article
- Modification by glucose of the flocculent phenotype of a Kloeckera apiculata wine strain.Journal of industrial microbiology & biotechnology · 2008Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the yeast Saccharomyces diastaticus, expression of the STA1 gene, which encodes an extracellular glucoamylase, is activated by the specific DNA-binding activators Flo8, Mss11, Ste12, and Tec1 and the Swi/Snf chromatin-remodeling complex. Here we show that Flo8 interacts physically and functionally with Mss11. Flo8 and Mss11 bind cooperatively to the inverted repeat sequence TTTGC-n-GCAAA (n = 97) in UAS1-2 of the STA1 promoter. In addition, Flo8 and Mss11 bind indirectly to UAS2-1 of the STA1 promoter by interacting with Ste12 and Tec1, which bind to the filamentation and invasion response element (FRE) in UAS2-1. Furthermore, our findings indicate that the Ste12, Tec1, Flo8, and Mss11 activators and the Swi/Snf complex bind sequentially to the STA1 promoter, as follows: Ste12 and Tec1 bind first to the FRE, whereby they recruit the Swi/Snf complex to the STA1 promoter. Next, the Swi/Snf complex enhances Flo8 and Mss11 binding to UAS1-2. In the final step, Flo8 and Mss11 directly promote association of RNA polymerase II with the STA1 promoter to activate STA1 expression. In the absence of glucose, the levels of Flo8 and Tec1 are greatly increased, whereas the abundances of two repressors, Nrg1 and Sfl1, are reduced, suggesting that the balance of transcriptional regulators may be important for determining activation or repression of STA1 expression.
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