ArticleWorld journal of gastroenterology2004
Coxsackievirus B3 infection and its mutation in Keshan disease.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 28 citations in OpenAlex.
- Biological Activity of Selenium and Its Impact on Human Health.International journal of molecular sciences · 2023Review
- The Effects of Selenium on Bone Health: From Element to Therapeutics.Molecules (Basel, Switzerland) · 2022Review
- Spatial Epidemiological Analysis of Keshan Disease in China.Annals of global health · 2022Article
- The epidemiological status, environmental and genetic factors in the etiology of Keshan disease.Cardiovascular endocrinology & metabolism · 2021Review
- Keshan Disease: A Potentially Fatal Endemic Cardiomyopathy in Remote Mountains of China.Frontiers in pediatrics · 2021Review
- Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19).Frontiers in nutrition · 2020Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate coxsackievirus B(3) infection and its gene mutation in Keshan disease.
methodsThe expression of Coxsackievirus B(3) RNA was detected in autopsy specimens of acute (12 cases), sub-acute (27 cases) and chronic (15 cases) Keshan disease by in situ hybridization. In sub-acute Keshan disease specimens, 3 cases with positive result by in situ hybridization were selected RT-PCR analysis. The DNA segments were then sequenced.
resultsCoxsackievirus B(3) RNA was detected in the cytoplasm of myocardiocyte. The positive rate was 83% in acute, 67% in sub-acute and 80% in chronic Keshan disease. In the conservative region of Coxsackievirus B(3) genome, there was a mutation in 234 (C-T) compared to the non-cardiovirulent strain, CVB(3/0).
conclusionCoxsackievirus B(3) RNA can survive and replicate in heart muscle of Keshan disease, which may play an important role in the occurrence of Keshan disease. The possible mechanism of occurrence of Keshan disease is associated with point a mutation in Coxsackievirus B(3) genome.
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