ArticleWorld journal of gastroenterology2004
Expression level of wild-type survivin in gastric cancer is an independent predictor of survival.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis.PloS one · 2016Pooled it
- Survivin/BIRC5-derived peptide disrupts survivin dimerization and cell division and induces multifaceted anti-cancer effects.Molecular therapy. Oncology · 2026Article
- A combined bioinformatics and experimental approach identifies RMI2 as a Wnt/β-catenin signaling target gene related to hepatocellular carcinoma.BMC cancer · 2023Article
- Evaluation of survivin splice variants in pituitary tumors.Pituitary · 2015Article
- Early diagnostic value of survivin and its alternative splice variants in breast cancer.BMC cancer · 2014Article
- Expression of survivin and its four splice variants in colorectal cancer and its clinical significances.Medical oncology (Northwood, London, England) · 2013Article
- Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR.World journal of gastroenterology · 2011Article
- Molecular characterization of the DYX1C1 gene and its application as a cancer biomarker.Journal of cancer research and clinical oncology · 2009Article
- The clinical significance of splice variants and subcellular localisation of survivin in non-small cell lung cancers.British journal of cancer · 2008Article
- The mechanism of methylselenocysteine and docetaxel synergistic activity in prostate cancer cells.Molecular cancer therapeutics · 2006Article
- Survivin as a prognostic factor for osteosarcoma patients.Acta histochemica et cytochemica · 2006Article
- Role of survivin and its splice variants in tumorigenesis.British journal of cancer · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimSurvivin is a novel antiapoptotic gene in which three splicing variants have been recently cloned and characterized. Survivin has been found to be abundantly expressed in a wide variety of human malignancies, whereas it is undetectable in normal adult tissues. We aimed to study the expression of three survivin splicing variants in gastric cancer, and to evaluate the prognostic significance of the expression of survivin variants in gastric cancer.
methodsReal time quantitative RT-PCR was performed to analyze the expression of survivin variants in 79 paired tumors and normal gastric mucosa samples at the mRNA level. Proliferative and apoptotic activity was measured using Ki-67 immunohistochemical analysis and the TUNEL method, respectively.
resultsAll the cases tested expressed wild-type survivin mRNA, which was not only the dominant transcript, but also a poor prognostic biomarker (P = 0.003). Non-antiapoptostic survivin-2B mRNA was correlated with tumor stage (P = 0.001), histological type (P = 0.004), and depth of tumor invasion (P = 0.041), while survivin-DeltaEx3 mRNA showed a significant association with apoptosis (P = 0.02).
conclusionWild-type survivin mRNA expression levels are of important prognostic value and significant participation of survivin-2B and survivin-DeltaEx3 is suggested in gastric cancer development.
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