ArticleLeukemia2004
Evidence of biased immunoglobulin variable gene usage in highly stable B-cell chronic lymphocytic leukemia.
Article in Leukemia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Topological Structures in the Space of Treatment-Naïve Patients with Chronic Lymphocytic Leukemia.Cancers · 2024Article
- Genetic landscape of ultra-stable chronic lymphocytic leukemia patients.Annals of oncology : official journal of the European Society for Medical Oncology · 2018Article
- Mimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation.British journal of cancer · 2016Article
- Prognostic signature and clonality pattern of recurrently mutated genes in inactive chronic lymphocytic leukemia.Blood cancer journal · 2015Article
- Characterization of a new chronic lymphocytic leukemia cell line for mechanistic in vitro and in vivo studies relevant to disease.PloS one · 2013Article
- CD69 is independently prognostic in chronic lymphocytic leukemia: a comprehensive clinical and biological profiling study.Haematologica · 2012Article
- The relationship between CD27 negative and positive B cell populations in human peripheral blood.Frontiers in immunology · 2011Article
- Article
- Computational identification of CDR3 sequence archetypes among immunoglobulin sequences in chronic lymphocytic leukemia.Leukemia research · 2009Article
- Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients.The Journal of clinical investigation · 2008Article
- Telomere length identifies two different prognostic subgroups among VH-unmutated B-cell chronic lymphocytic leukemia patients.Leukemia · 2007Article
- Article
- Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries.Blood · 2006Article
- Chromosome abnormalities with prognostic impact in B-cell chronic lymphocytic leukemia.Pathology oncology research : POR · 2005Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recognition of biased immunoglobulin variable (IgV) gene usage in B-cell chronic lymphocytic leukemia (B-CLL) may yield insight into leukemogenesis and may help to refine prognostic categories. We explored Ig variable heavy (VH) and light (VL) chain gene usage in highly stable and indolent B-CLL (n=25) who never required treatment over 10 or more years. We observed an unexpectedly high usage of mutated VH3-72 (6/25; 24.0%), a gene that was otherwise rare in B-CLL (7/805; 0.87%; P<0.01), including mutated cases (6/432; 1.39%; P<0.01) and was exceptional among indolent (1/230, 0.435%; P<0.01), and aggressive B-cell lymphomas (0/105; P<0.01). Three of six VH3-72 B-CLL cases utilized the same VL Vkappa4-1 gene. Two V(H)3-72 B-CLL cases had highly homologous VH complementarity determining regions 3 (CDR3s), encoding Cys-XXXX-Cys domains, and utilized Vkappa4-1 genes with homologous IgVL CDR3s. An identical threonine to isoleucine change at codon 84 of V(H)3-72 framework region 3 (FR3) recurred in four cases of highly stable VH3-72 B-CLL. This mutation is expected to cause a conformational change of FR3 proximal to CDR3 that might critically affect high-affinity antigen binding. B-cell receptors encoded by VH3-72 may identify a specific B-CLL group and be implicated in leukemogenesis through an antigen-driven expansion of B cells.
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