ArticleGenes and immunity2004
Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn's disease.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Genetic Association between Interleukin Genes and Alopecia Areata in Jordanian Patients.Oman medical journal · 2022Article
- IL12B and IL23R polymorphisms are associated with alopecia areata.Genes and immunity · 2020Article
- Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan.Scientific reports · 2017Article
- Association of the interleukin-12 polymorphic variants with the development of antibodies to surface antigen of hepatitis B virus in hemodialysis patients in response to vaccination or infection.Molecular biology reports · 2013Article
- The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches.Expert review of vaccines · 2013Review
- Association between single-nucleotide polymorphisms in interleukin-12A and risk of chronic obstructive pulmonary disease.DNA and cell biology · 2012Article
- Functional genetic polymorphisms in interleukin-12B gene in association with systemic lupus erythematosus.Rheumatology international · 2012Article
- Article
- A polymorphism in the coding region of Il12b promotes IL-12p70 and IL-23 heterodimer formation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults.Immunogenetics · 2010Article
- IL12B polymorphisms are linked but not associated with Plasmodium falciparum parasitemia: a familial study in Burkina Faso.Genes and immunity · 2008Article
- Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma.Blood · 2008Article
- Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.Nature genetics · 2007Article
- A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.American journal of human genetics · 2007Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-12 (IL-12) is a key cytokine for the induction of Th1 immune responses. Recently, functional polymorphisms in IL-12p40 (IL12B) were found to be associated with susceptibility to several autoimmune diseases. Similarly, variation in IL12B might be involved in susceptibility to Crohn's disease (CD), a chronic inflammatory bowel disorder associated with high IL-12 expression. We searched for additional polymorphism in IL12B and genotyped a large cohort of CD patients. Differential in vitro secretors of IL-12 were tested for polymorphism. Polymorphisms were analyzed using the intrafamilial transmission disequilibrium test (TDT) and by case-control analysis. A novel polymorphism was strongly associated with differential expression of IL-12. However, no association with susceptibility to CD was seen for this and other polymorphisms. The high level of conservation is consistent with the key regulatory role of IL-12. The lack of association with IL12B makes it unlikely that this gene is directly involved in the susceptibility to CD.
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