ArticleGlycoconjugate journal2004
Specific and non specific interactions involving Le( X ) determinant quantified by lipid vesicle micromanipulation.
Article in Glycoconjugate journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Measuring pico-Newton Forces with Lipid Anchors as Force Sensors in Molecular Dynamics Simulations.The journal of physical chemistry. B · 2023Article
- Glycan-to-Glycan Binding: Molecular Recognition through Polyvalent Interactions Mediates Specific Cell Adhesion.Molecules (Basel, Switzerland) · 2021Review
- Membrane Adhesion via Glycolipids Occurs for Abundant Saccharide Chemistries.Biophysical journal · 2020Article
- Conformation of Single and Interacting Lipopolysaccharide Surfaces Bearing O-Side Chains.Biophysical journal · 2018Article
- Binding equilibrium and kinetics of membrane-anchored receptors and ligands in cell adhesion: Insights from computational model systems and theory.Cell adhesion & migration · 2016Review
- Single molecule study of heterotypic interactions between mucins possessing the Tn cancer antigen.Glycobiology · 2015Article
- Equilibrium-fluctuation-analysis of single liposome binding events reveals how cholesterol and Ca2+ modulate glycosphingolipid trans-interactions.Scientific reports · 2013Article
- Membrane adhesion via homophilic saccharide-saccharide interactions investigated by neutron scattering.Biophysical journal · 2011Article
- Cellular interaction through LewisX cluster: theoretical studies.Journal of molecular modeling · 2008Article
- First synthesis of two deoxy Lewis(x) pentaosyl glycosphingolipids.Glycoconjugate journal · 2008Article
- Lewis X oligosaccharides targeting to DC-SIGN enhanced antigen-specific immune response.Immunology · 2007Article
- Shear modulation of intercellular contact area between two deformable cells colliding under flow.Journal of biomechanics · 2007Article
- Molecular dynamics simulations and 2H NMR study of the GalCer/DPPG lipid bilayer.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbohydrate-carbohydrate recognition is emerging today as an important type of interaction in cell adhesion. One Ca(2+)mediated homotypic interaction between two Lewis( X ) determinants (Le( X )) has been proposed to drive cell adhesion in murine embryogenesis. Here, the adhesion energies of lipid vesicles functionalized with glycolipids bearing monomeric or dimeric Le( X ) determinants were measured in NaCl or CaCl(2) media with the micropipette aspiration technique. These experiments on Le( X ) with an environment akin to that provided by biological membrane confirmed the existence of this specific calcium dependent interaction of monomeric Le( X ). In contrast, dimeric Le( X ) produced a repulsive contribution. By using a simple model involving the various contributions to the adhesion free energy, specific and non specific interactions could be separated and quantified. The involvement of calcium ions has been discussed in the monomeric and dimeric Le( X ) lipids.
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