ArticleGlycoconjugate journal2004
Studies of the carbohydrate-carbohydrate interaction between lactose and GM(3) using Langmuir monolayers and glycolipid micelles.
Article in Glycoconjugate journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 27 citations in OpenAlex.
- The influence of ABO blood groups on COVID-19 susceptibility and severity: A molecular hypothesis based on carbohydrate-carbohydrate interactions.Medical hypotheses · 2020Article
- Synthetic Assembly of Mannose Moieties Using Polymer Chemistry and the Biological Evaluation of Its Interaction towards Concanavalin A.Molecules (Basel, Switzerland) · 2017Article
- Inhibition binding studies of glycodendrimer-lectin interactions using surface plasmon resonance.Tetrahedron · 2010Article
- Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes.Glycoconjugate journal · 2009Article
- Weak self-association in a carbohydrate system.Biophysical journal · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper describes studies of the carbohydrate-carbohydrate interaction (CCI) between micelles of a lactosyl lipid and monolayers of the glycosphingolipid GM(3). The lactose Lac.GM(3) interaction is involved in B16 melanoma cell adhesion and signaling processes, and a thorough understanding of the molecular details of this CCI is important for the design of new anti-adhesive and anti-metastatic agents. In this paper, we examine the influence of variations in divalent cations and subphase ionic strength on the Lac.GM(3) interaction. Our results indicate that, in the absence of divalent cations, the Lac.GM(3) CCI is strengthened at higher sodium chloride concentrations in the subphase. In contrast, when divalent cations are present in solution, the CCI is not as sensitive to ionic strength. These results suggest a role for both cation dependent as well as independent interactions in the Lac.GM(3) CCI.
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Registered trials
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