ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
In vivo trafficking and targeting of N-cadherin to nascent presynaptic terminals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Cadherins regulate nuclear topography and function of developing ocular motor circuitry.eLife · 2020Article
- The Cadherin Superfamily in Neural Circuit Assembly.Cold Spring Harbor perspectives in biology · 2018Review
- Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity.Neurotoxicology · 2018Review
- Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation.iScience · 2018Article
- N-Cadherin is Involved in Neuronal Activity-Dependent Regulation of Myelinating Capacity of Zebrafish Individual Oligodendrocytes In Vivo.Molecular neurobiology · 2017Article
- Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders.Neural plasticity · 2017Review
- Cadherin-2 Is Required Cell Autonomously for Collective Migration of Facial Branchiomotor Neurons.PloS one · 2016Article
- Cadherin-based transsynaptic networks in establishing and modifying neural connectivity.Current topics in developmental biology · 2015Review
- The classic cadherins in synaptic specificity.Cell adhesion & migration · 2015Review
- Article
- Glial cell-derived neurotrophic factor attenuates neuropathic pain in a mouse model of chronic constriction injury: possible involvement of E-cadherin/p120ctn signaling.Journal of molecular neuroscience : MN · 2014Article
- Late recruitment of synapsin to nascent synapses is regulated by Cdk5.Cell reports · 2013Article
- N-cadherin relocalizes from the periphery to the center of the synapse after transient synaptic stimulation in hippocampal neurons.PloS one · 2013Article
- Early development of the gonadotropin-releasing hormone neuronal network in transgenic zebrafish.Frontiers in endocrinology · 2013Article
- N-cadherin prodomain processing regulates synaptogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Slit1b-Robo3 signaling and N-cadherin regulate apical process retraction in developing retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo.Hippocampus · 2012Article
- Time-lapse imaging of neural development: zebrafish lead the way into the fourth dimension.Genesis (New York, N.Y. : 2000) · 2011Review
- GlycoFish: a database of zebrafish N-linked glycoproteins identified using SPEG method coupled with LC/MS.Analytical chemistry · 2011Article
- N-cadherin regulates primary motor axon growth and branching during zebrafish embryonic development.The Journal of comparative neurology · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-cadherin is a prominent component of developing and mature synapses, yet very little is known about its trafficking within neurons. To investigate N-cadherin dynamics in developing axons, we used in vivo two-photon time-lapse microscopy of N-cadherin--green fluorescent protein (Ncad-GFP), which was expressed in Rohon-Beard neurons of the embryonic zebrafish spinal cord. Ncad-GFP was present as either stable accumulations or highly mobile transport packets. The mobile transport packets were of two types: tubulovesicular structures that moved preferentially in the anterograde direction and discrete-punctate structures that exhibited bidirectional movement. Stable puncta of Ncad-GFP accumulated in the wake of the growth cone with a time course. Colocalization of Ncad-GFP puncta with synaptic markers suggests that N-cadherin is a very early component of nascent synapses. Expression of deletion mutants revealed a potential role of the extracellular domain in appropriate N-cadherin trafficking and targeting. These results are the first to characterize the trafficking of a synaptic cell-adhesion molecule in developing axons in vivo. In addition, we have begun to investigate the cell biology of N-cadherin trafficking and targeting in the context of an intact vertebrate embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.