ArticleMolecular biology of the cell2005
Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A'.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 112 citations in OpenAlex.
- Article
- Rab6-mediated retrograde trafficking from the Golgi: the trouble with tubules.Small GTPases · 2023Review
- RAB6 and dynein drive post-Golgi apical transport to prevent neuronal progenitor delamination.EMBO reports · 2022Article
- Loss of MUNC18-1 leads to retrograde transport defects in neurons.Journal of neurochemistry · 2021Article
- Unveiling the Physical and Functional Niches of FAM26F by Analyzing Its Subcellular Localization and Novel Interacting Partners.ACS omega · 2020Article
- Antiparasitic dibenzalacetone inhibits the GTPase activity of Rab6 protein of Leishmania donovani (LdRab6), a potential target for its antileishmanial effect.Parasitology research · 2020Article
- In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation.Nature communications · 2020Article
- Article
- Critical importance of RAB proteins for synaptic function.Small GTPases · 2018Review
- Rab proteins as major determinants of the Golgi complex structure.Small GTPases · 2018Review
- Involvement of Rab6a in organelle rearrangement and cytoskeletal organization during mouse oocyte maturation.Scientific reports · 2016Article
- Review
- Identification of Rab41/6d Effectors Provides an Explanation for the Differential Effects of Rab41/6d and Rab6a/a' on Golgi Organization.Frontiers in cell and developmental biology · 2016Article
- How Rab proteins determine Golgi structure.International review of cell and molecular biology · 2015Review
- High-content analysis of Rab protein function at the ER-Golgi interface.Bioarchitecture · 2015Article
- The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.Membranes · 2014Review
- Distinct sets of Rab6 effectors contribute to ZW10--and COG-dependent Golgi homeostasis.Traffic (Copenhagen, Denmark) · 2014Article
- Rab6 dependent post-Golgi trafficking of HSV1 envelope proteins to sites of virus envelopment.Traffic (Copenhagen, Denmark) · 2014Article
- A role for endoplasmic reticulum exit sites in foot-and-mouth disease virus infection.The Journal of general virology · 2013Article
- Structural basis of membrane trafficking by Rab family small G protein.International journal of molecular sciences · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The small GTPase rab6A but not the isoform rab6A' has previously been identified as a regulator of the COPI-independent recycling route that carries Golgi-resident proteins and certain toxins from the Golgi to the endoplasmic reticulum (ER). The isoform rab6A' has been implicated in Golgi-to-endosomal recycling. Because rab6A but not A', binds rabkinesin6, this motor protein is proposed to mediate COPI-independent recycling. We show here that both rab6A and rab6A' GTP-restricted mutants promote, with similar efficiency, a microtubule-dependent recycling of Golgi resident glycosylation enzymes upon overexpression. Moreover, we used small interfering RNA mediated down-regulation of rab6A and A' expression and found that reduced levels of rab6 perturbs organization of the Golgi apparatus and delays Golgi-to-ER recycling. Rab6-directed Golgi-to-ER recycling seems to require functional dynactin, as overexpression of p50/dynamitin, or a C-terminal fragment of Bicaudal-D, both known to interact with dynactin inhibit recycling. We further present evidence that rab6-mediated recycling seems to be initiated from the trans-Golgi network. Together, this suggests that a recycling pathway operates at the level of the trans-Golgi linking directly to the ER. This pathway would be the preferred route for both toxins and resident Golgi proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.