ArticleDigestive diseases and sciences2004
The Helicobacter pylori restriction endonuclease-replacing gene, hrgA, and clinical outcome: comparison of East Asia and Western countries.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Increased Risk of Severe Gastric Symptoms by Virulence FactorsJournal of microbiology and biotechnology · 2021Article
- Article
- The Effects of Helicobacter pylori on the prognosis of patients with curatively resected gastric cancers in a population with high infection rate.Journal of the Korean Surgical Society · 2012Article
- Identification of new homologs of PD-(D/E)XK nucleases by support vector machines trained on data derived from profile-profile alignments.Nucleic acids research · 2011Article
- Helicobacter pylori vacA arrangement and related diseases: a retrospective study over a period of 15 years.Digestive diseases and sciences · 2009Article
- Latest insights into the effects of Helicobacter pylori infection on gastric carcinogenesis.World journal of gastroenterology · 2006Review
- Article
- Duodenal ulcer promoting gene of Helicobacter pylori.Gastroenterology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
It has been suggested that the putative Helicobacter pylori virulence factor hrgA is the first disease-specific marker for an H. pylori-related disease, (i.e., development of gastric cancer in East Asia). Our aim was to test the hypothesis that the presence of hrgA has disease specificity. We examined 458 H. pylori isolates including 289 from East Asia and 169 from Western countries whose cagA and vacA genotypes had previously been characterized. hrgA/hpyIIIR status and iceA genotypes were determined by polymerase chain reaction using DNA expanded from a single colony. hrgA was present in 29% of gastric cancers, 29% of ulcers, and 31% of gastritis cases among H. pylori from East Asia (P > 0.9). Overall, there was no significant relationship between the presence of the hrgA gene and disease presentation (cancer, ulcer, or neither) or between its presence and the cag pathogenicity island, vacA s1 , babA2, and oipA, "on" genotypes. The prevalence of the hrgA gene was significantly lower in H. pylori from East Asia (29%) vs. those from the West (49%) (P < 0.001). The prevalence of the hrgA gene was not related to clinical outcome or to other important putative virulence factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.