ArticleDigestive diseases and sciences2004
Protective effect of lactulose on dextran sulfate sodium-induced colonic inflammation in rats.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 88 citations in OpenAlex.
- Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study.BMC gastroenterology · 2007Trial
- The effects of dietary beef powder on the dextran sulfate sodium-induced colitis in a mouse model through COX-2 pathway.Food science of animal resources · 2026Article
- Protective effect of low-dose lactulose in dextran sulfate sodium induced ulcerative colitis model of rats.Scientific reports · 2025Article
- The synergic impact of lignin and Lactobacillus plantarum on DSS-induced colitis model via regulating CD44 and miR 199a alliance.World journal of microbiology & biotechnology · 2022Article
- Ameliorative effect of two structurally divergent hydrazide derivatives against DSS-induced colitis by targeting Nrf2 and NF-κB signaling in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2022Article
- Protective effect of 17S‑epoxy‑docosapentaenoic acid against dextran sulfate sodium induced ulcerative colitis in BALB/c mice.Molecular medicine reports · 2022Article
- Mediterranean Diet: Prevention of Colorectal Cancer.Frontiers in nutrition · 2017Review
- Double-blind controlled randomised study of lactulose and lignin hydrolysed combination in complex therapy of atopic dermatitis.Microbial ecology in health and disease · 2016Article
- Diet and Inflammatory Bowel Disease.Gastroenterology & hepatology · 2015Article
- The Synergic Anti-inflammatory Impact of Gleditsia sinensis Lam. and Lactobacillus brevis KY21 on Intestinal Epithelial Cells in a DSS-induced Colitis Model.Korean journal for food science of animal resources · 2015Article
- Pathobiology and potential therapeutic value of intestinal short-chain fatty acids in gut inflammation and obesity.Digestive diseases and sciences · 2013Review
- The interplay between fiber and the intestinal microbiome in the inflammatory response.Advances in nutrition (Bethesda, Md.) · 2013Review
- Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats.Medical gas research · 2012Article
- Lactulose: an effective preventive and therapeutic option for ischemic stroke by production of hydrogen.Medical gas research · 2012Article
- Modulation of PPAR-γ by Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases.PPAR research · 2012Article
- Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis.The American journal of pathology · 2009Article
- Prebiotics in chronic intestinal inflammation.Inflammatory bowel diseases · 2009Review
- Probiotics and prebiotics in inflammatory bowel disease: microflora 'on the scope'.British journal of clinical pharmacology · 2008Review
- Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease.World journal of gastroenterology · 2007Article
- Fructo-oligosaccharide reduces inflammation in a dextran sodium sulphate mouse model of colitis.Digestive diseases and sciences · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Promising results have recently been obtained with pre- and probiotic therapy in ulcerative colitis (UC). The prebiotic potential of lactulose is well established, but it has not yet been investigated in experimental colitis models. The purpose of the study was to examine the effect of lactulose on an UC model induced by 3% dextran sulfate sodium (DSS) solution added to drinking water for 7 days in male Wistar rats. Lactulose (300-1000 mg/kg) or 5-aminosalicylic acid (5-ASA; 150 mg/kg) was administered orally twice daily for 6 days. Colonic ulceration area, colon length, body weight changes, diarrhea/bloody feces, colonic mucosal myeloperoxidase activity (MPO), thiobarbituric acid reactive substances (TBARS), and histology were examined. Treatment of animals with DSS for 7 days resulted in severe colonic lesions accompanied by diarrhea, bloody feces, a decrese in body weight, shortening of the colon length, and an increase in MPO activity as well as TBARS, compared to normal rats. Lactulose treatment ameliorated DSS-induced colitis in a dose-dependent manner, and at 1000 mg/kg all of the parameters examined, except TBARS, were shown to improve significantly as compared to controls. Daily administration of 5-ASA also significantly reduced the severity of colonic lesions following DSS treatment. These results demonstrated the protective effect of lactulose in this rat colitis model and suggested that the background of this lactulose effect may be due to alterations of colonic microflora.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.