ArticleDigestive diseases and sciences2004
Relationship between fecal calprotectin, intestinal inflammation, and peripheral blood neutrophils in patients with active ulcerative colitis.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Mesenchymal stem cells for the treatment of ulcerative colitis: a systematic review and meta-analysis of experimental and clinical studies.Stem cell research & therapy · 2019Pooled it
- The role of neutrophils in the pathophysiology of inflammatory bowel diseases.Periodontology 2000 · 2025Review
- The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis.Bioscience reports · 2025Article
- Review on Advances in Pediatric Endoscopy in the Management of Inflammatory Bowel Disease.Current pediatric reviews · 2025Review
- Mechanism of Morbidity Based on Ulcerative Colitis: A Review of Traditional Chinese Medicine Treatment of Ulcerative Colitis.International journal of general medicine · 2025Review
- Underneath the Gut-Brain Axis in IBD-Evidence of the Non-Obvious.International journal of molecular sciences · 2024Review
- Review
- Identification of ferroptosis-related genes in ulcerative colitis: a diagnostic model with machine learning.Annals of translational medicine · 2023Article
- Hyaluronic Acid in Synovial Fluid Prevents Neutrophil Activation in Spondyloarthritis.International journal of molecular sciences · 2023Article
- Endoscopy for assessment of mucosal healing in ulcerative colitis: time bound or response guided?Intestinal research · 2022Article
- NET Release of Long-Term Surviving Neutrophils.Frontiers in immunology · 2022Article
- Identification of Immune-Related Gene Signature and Prediction of CeRNA Network in Active Ulcerative Colitis.Frontiers in immunology · 2022Article
- Neutrophil-T cell crosstalk in inflammatory bowel disease.Immunology · 2021Review
- Inflammatory Bowel Disease and Neutrophil-Lymphocyte Ratio: A Systematic Scoping Review.Journal of clinical medicine · 2021Article
- Diagnostic accuracy of fecal calprotectin in predicting significant gastrointestinal diseases.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Clinical Value of Fecal Calprotectin in Predicting Mucosal Healing in Patients With Ulcerative Colitis.Frontiers in medicine · 2021Article
- Assessing Severity of Disease in Patients with Ulcerative Colitis.Gastroenterology clinics of North America · 2020Review
- Calprotectin in inflammatory bowel disease.Clinica chimica acta; international journal of clinical chemistry · 2020Review
- Diagnostic utility of the neutrophil-platelet ratio as a novel marker of activity in patients with Ulcerative Colitis.PloS one · 2020Article
- Patient self-reported symptoms using visual analog scales are useful to estimate endoscopic activity in ulcerative colitis.Intestinal research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Active ulcerative colitis (UC) is associated with elevated granulocytes and monocytes/macrophages (GM) which show activation behavior and increased survival time. Further, fecal calprotectin (a stable neutrophil protein) level parallels intestinal inflammation and can predict UC relapse. Since GM are major sources of inflammatory cytokines and chemokines, they are suspected to have roles in the initiation and perpetuation of UC. Our objective was to investigated relationships between peripheral blood (PB) neutrophils, calprotectin, and UC disease activity. Full PB and calprotectin were determined in 69 healthy controls and 31 patients with UC, then 7 randomly selected patients received GM adsorptive apheresis (GMA) with Adacolumn, 10 sessions of 60-min duration each. Patients with UC had higher neutrophil counts (P < 0.001), but lower lymphocyte counts (P < 0.001) compared with controls. Further, fecal calprotectin levels showed a correlation with UC clinical activity index (CAI; P < 0.001) and mucosal inflammation (P < 0.001). Following GMA, there were falls in neutrophils (P < 0.02), CAI (P < 0.02) and calprotectin (P < 0.02). In conclusion, GM appear to contribute to intestinal inflammation and UC activity and reduction of these cells by GMA should benefit patients with active UC. Further, the correlations among calprotectin, UC activities, and PB neutrophils should serve as the basis for preemptive actions to control this disease.
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