Evidence map›Paper›PMID 15481305›Full record

ReviewDigestive diseases and sciences2004

Ischemia-reperfusion injury of the intestine and protective strategies against injury.

Ismail Hameed Mallick, Wenxuan Yang, Marc C Winslet, Alexander M Seifalian

Abstract readReview
PubMed Publisher
In one paragraph

Review in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 239 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
239citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

239 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Observational
  9. Review
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  12. Review
  13. Protective activity ofPharmaceutical science advances · 2025
    Article
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  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
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179 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ismail Hameed MallickGI & Hepatobiliary Research Unit, University Department of Surgery, Royal Free and University College Medical School, University College London, London NW3 2PF, UK.
Wenxuan Yang
Marc C Winslet
Alexander M Seifalian

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia-reperfusion injury of the intestine is a significant problem in abdominal aortic aneurysm surgery, small bowel transplantation, cardiopulmonary bypass, strangulated hernias, and neonatal necrotizing enterocolitis. It can also occur as a consequence of collapse of systemic circulation, as in hypovolemic and septic shock. It is associated with a high morbidity and mortality. This article is a comprehensive review of the current status of the molecular biology and the strategies to prevent ischemia-reperfusion injury of the intestine. Various treatment modalities have successfully been applied to attenuate reperfusion injury in animal models of reperfusion injury of the intestine. Ischemic preconditioning has been found to be the most promising strategy against reperfusion injury during the last few years, appearing to increase the tolerance of the intestine to reperfusion injury. Although ischemic preconditioning has been shown to be beneficial in the human heart and the liver, prospective controlled studies in humans involving ischemic preconditioning of the intestine are lacking. Research focused on the application of novel drugs that can mimic the effects of ischemic preconditioning to manipulate the cellular events during reperfusion injury of the intestine is required.

Indexed as

AnimalsBiomarkersEndothelinsHeat-Shock ProteinsHumansInflammation MediatorsIntestine, LargeIntestine, SmallIschemiaIschemic PreconditioningNitric OxidePrognosisRatsReperfusion InjurySeverity of Illness IndexSurvival AnalysisBiomarkersEndothelinsHeat-Shock ProteinsInflammation MediatorsNitric OxideXanthine Oxidase

Identifiers

PMID15481305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.