ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2004
Pharmacological treatment of reflex syncope.
Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Drugs and pacemakers for vasovagal, carotid sinus and situational syncope.The Cochrane database of systematic reviews · 2011Pooled it
- The effects of a novel "fluid loading" strategy on cardiovascular and haematological responses to orthostatic stress.European journal of applied physiology · 2009Trial
- Increased hydration alone does not improve orthostatic tolerance in patients with neurocardiogenic syncope.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2007Trial
- Baseline heart rate variability in children and adolescents with vasovagal syncope.Korean journal of pediatrics · 2014Article
- Blood pressure regulation X: what happens when the muscle pump is lost? Post-exercise hypotension and syncope.European journal of applied physiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patient education, identification of possible triggers of syncope and reassurance are a central feature of the management of patients with reflex syncope. Patients should be advised as to the importance of adequate hydration and taught physical countermaneuvers to enhance cardiac venous return. These maneuvers are sufficient for most patients, however, for a small number of patients who continue to have recurrent syncopal events, pharmacological intervention may be considered. Volume expansion can be enhanced with salt and fludrocortisone. Agents from diverse pharmacological classes have been used to attenuate the reflex response, enhance vasoconstriction and attenuate vagal outflow. Alpha adrenoreceptor agonists, anticholinergic agents, theophylline, beta adrenoreceptor antagonists, serotonin reuptake inhibitors and disopyramide are the most widely studied. None of these agents has shown a consistent therapeutic benefit in clinical trials.
Indexed as
Identifiers
15480933What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.