ArticleMolecular genetics and genomics : MGG2004
The ire1 and ptc2 genes involved in the unfolded protein response pathway in the filamentous fungus Trichoderma reesei.
Article in Molecular genetics and genomics : MGG, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 39 citations in OpenAlex.
- Trichoderma reesei Cellulase in the Monoculture and the Mixed Culture with Aspergillus niger: From Transcripts to Proteins.Applied biochemistry and biotechnology · 2025Article
- Protein secretion and associated stress in industrially employed filamentous fungi.Applied microbiology and biotechnology · 2024Review
- The ERAD Pathway Participates in Fungal Growth and Cellulase Secretion inJournal of fungi (Basel, Switzerland) · 2023Article
- The Unfolded Protein Response: An Overview.Biology · 2021Review
- Tracking localization and secretion of cellulase spatiotemporally and directly in livingBiotechnology for biofuels · 2019Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- Effect of earlier unfolded protein response and efficient protein disposal system on cellulase production in Rut C30.World journal of microbiology & biotechnology · 2014Article
- Systems biological approaches towards understanding cellulase production by Trichoderma reesei.Journal of biotechnology · 2013Review
- Article
- Detecting novel genes with sparse arrays.Gene · 2010Article
- Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism.RNA (New York, N.Y.) · 2010Review
- Overexpression of bacterial ethylene-forming enzyme gene in Trichoderma reesei enhanced the production of ethylene.International journal of biological sciences · 2010Article
- Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae.BMC genomics · 2006Article
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3 authors at 1 institution in 1 country.
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Abstract
A signal transduction pathway called the unfolded protein response is activated when increased levels of misfolded proteins or incorrectly assembled subunits accumulate in the endoplasmic reticulum (ER). The expression of several genes for ER-resident foldases and chaperones, as well as genes encoding proteins that are involved in functions associated with the secretory process, are induced by this pathway. This paper describes the cloning and characterisation of genes for two components of the pathway, ire1 and ptc2, from the filamentous fungus Trichoderma reesei (Hypocrea jecorina). The data presented demonstrates that the T. reesei genes can complement Saccharomyces cerevisiae mutants that are deficient in the corresponding homologues. The T. reesei IREI protein has intrinsic kinase activity, as revealed by an in vitro autophosphorylation assay. Overexpression of ire1 in a T. reesei strain that expresses a foreign protein (laccase 1 from Phlebia radiata), results in up-regulation of the UPR pathway, as indicated by the increased expression levels of the known UPR target genes bip1 and pdi1. Splicing of the mRNA encoding the transcription factor HAC1 is also observed. Other genes encoding proteins from different parts of the secretory pathway also respond to ire1 overexpression.
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