ArticleVirchows Archiv : an international journal of pathology2004
p16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri.
Article in Virchows Archiv : an international journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- p16 immunostaining in histological grading of anal squamous intraepithelial lesions: a systematic review and meta-analysis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Pooled it
- p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis.Cancer treatment reviews · 2009Pooled it
- Efficacy and safety of an adsorbent and anti-oxidative vaginal gel on CIN1 and 2, on high-risk HPV, and on p16/Ki-67: a randomized controlled trial.Archives of gynecology and obstetrics · 2021Trial
- Immunohistochemical Expression of P16 in Cervical Lesions: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Biomarkers differentiating regression from progression among untreated cervical intraepithelial neoplasia grade 2 lesions.Journal of advanced research · 2025Review
- Immunohistochemistry staining of Eag1 and p16/Ki-67 can help improve the management of patients with cervical intraepithelial Neoplasia after cold knife conversion.Diagnostic pathology · 2024Article
- Article
- An Emerging Anti-p16 Antibody-BC42 Clone as an Alternative to the Current E6H4 for Use in the Female Genital Tract Pathological Diagnosis: Our Experience and a Review on p16ink4a Functional Significance, Role in Daily-Practice Diagnosis, Prognostic Potential, and Technical Pitfalls.Diagnostics (Basel, Switzerland) · 2021Article
- Progression of Precancerous Cervical Lesion Predicted by p16 Protein Immunohistochemistry in Rajavithi Hospital.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- p16INK4a and Ki-67 measurement predict progression of cervical low-grade squamous intraepithelial lesion.International journal of clinical and experimental pathology · 2018Article
- Utility of P16/INK4a and Ki-67 in Preneoplasticand Neoplastic Lesions of Cervix.Iranian journal of pathology · 2018Article
- Usefulness of p16Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Observational
- Introduction of p16Infectious agents and cancer · 2017Article
- [Modern biomarkers for precancerous lesions of the uterine cervix : Histological-cytological correlation and use].Der Pathologe · 2016Review
- p16 staining has limited value in predicting the outcome of histological low-grade squamous intraepithelial lesions of the cervix.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- TMEM45A, SERPINB5 and p16INK4A transcript levels are predictive for development of high-grade cervical lesions.American journal of cancer research · 2016Article
- Expression of P16 in high-risk human papillomavirus related lesions of the uterine cervix in a government hospital, Malaysia.Diagnostic pathology · 2014Article
- p16(INK4a) immunoprofiles of squamous lesions of the uterine cervix-implications for the reclassification of atypical immature squamous metaplasia.Pathology oncology research : POR · 2013Article
- Cervical squamocolumnar junction-specific markers define distinct, clinically relevant subsets of low-grade squamous intraepithelial lesions.The American journal of surgical pathology · 2013Article
- p16(INK4a) immunohistochemistry is a promising biomarker to predict the outcome of low grade cervical intraepithelial neoplasia: comparison study with HPV genotyping.Journal of gynecologic oncology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to evaluate the immunohistochemical expression of p16INK4a as a marker of progression risk in low-grade dysplastic lesions of the cervix uteri. p16INK4a immunohistochemistry was performed on 32 CIN1 with proven spontaneous regression of the lesion in the follow-up (group A), 31 (group B) with progression to CIN3 and 33 (group C) that were randomly chosen irrespective of the natural history of the lesion. p16INK4a staining pattern was scored as negative (less than 5% cells in the lower third of dysplastic epithelium stained), as focally positive (< or = 25%) and as diffuse positive (> 25%). A diffuse staining pattern was detected in 43.8% of CIN1 of group A, 74.2% of group B and 56.3% of group C. No p16INK4a staining was detected in 31.3% and 12.9% CIN1 lesions of groups A and B, respectively. Overall, 71.4% and 37.8% of p16INK4a-negative and diffusely positive CIN1 had regressed at follow-up, whereas 28.6% and 62.2% negative and diffusely positive CIN1 were progressed to CIN3, respectively (P < 0.05). All CIN3 lesions analyzed during follow-up of group B were diffusely stained for p16INK4a. Although p16INK4a may be expressed in low-grade squamous lesions that undergo spontaneous regression, in this study, CIN1 cases with diffuse p16INK4a staining had a significantly higher tendency to progress to a high-grade lesion than p16INK4a-negative cases. p16INK4a may have the potential to support the interpretation of low-grade dysplastic lesions of the cervix uteri.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.