Trial reportAnnals of the rheumatic diseases2004
Long term high intensity exercise and damage of small joints in rheumatoid arthritis.
Trial report in Annals of the rheumatic diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00434200 (Interventional Study on the Effectiveness and Safety of Intensive Exercise in Patients With RA), which is not on this map. Cited by 34 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interventional Study on the Effectiveness and Safety of Intensive Exercise in Patients With RA
Who cites it
34 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Quality of reporting and nature of harms in clinical trials on supervised exercise in patients with rheumatoid arthritis or axial spondyloarthritis.Rheumatology international · 2024Pooled it
- Exercise for rheumatoid arthritis of the hand.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- A systematic review into the effectiveness of hand exercise therapy in the treatment of rheumatoid arthritis.Clinical rheumatology · 2014Pooled it
- A systematic review of the effects of dynamic exercise in rheumatoid arthritis.Rheumatology international · 2009Pooled it
- Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis.The Cochrane database of systematic reviews · 2009Pooled it
- Subjective and objective levels of physical activity and their association with cardiorespiratory fitness in rheumatoid arthritis patients.Arthritis research & therapy · 2015Trial
- Strengthening exercises to improve hand strength and functionality in rheumatoid arthritis with hand deformities: a randomized, controlled trial.Rheumatology international · 2013Trial
- The effects of strength and endurance training in patients with rheumatoid arthritis.Clinical rheumatology · 2011Trial
- Association of Physical Activity Patterns with the Metabolic Syndrome in Korean Adults: A Nationwide Cross-Sectional Study.Reviews in cardiovascular medicine · 2024Article
- Do Disease-Modifying Anti-rheumatic Drugs and Exercise Therapy Have a Combined Effect on Disease Activity in Patients with RA? A Scoping Review.Current rheumatology reports · 2023Article
- Inequity in exercise-based interventions for adults with rheumatoid arthritis: a systematic review.Rheumatology advances in practice · 2023Review
- Physical Activity Associates With Lower Systemic Inflammatory Gene Expression in Rheumatoid Arthritis.The Journal of rheumatology · 2022Observational
- Atomic Simulation of the Binding of JAK1 and JAK2 with the Selective Inhibitor Ruxolitinib.International journal of molecular sciences · 2022Article
- Review
- [Sports and exercise therapy in inflammatory rheumatic diseases].Zeitschrift fur Rheumatologie · 2021Article
- Evaluation of factors affecting the levels of physical activity in patients with rheumatoid arthritis: a cross-sectional study.Clinical rheumatology · 2019Article
- Article
- Physical activity for paediatric rheumatic diseases: standing up against old paradigms.Nature reviews. Rheumatology · 2017Review
- Pragmatic assessment of exercise in routine care using an MDHAQ: associations with changes in RAPID3 and other clinical variables.Arthritis research & therapy · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of long term high intensity weightbearing exercises on radiological damage of the joints of the hands and feet in patients with rheumatoid arthritis (RA).
methodsData of the 281 completers of a 2 year randomised controlled trial comparing the effects of usual care physical therapy (UC) with high intensity weightbearing exercises were analysed for the rate of radiological joint damage (Larsen score) of the hands and feet. Potential determinants of outcome were defined: disease activity, use of drugs, change in physical capacity and in bone mineral density, and attendance rate at exercise sessions.
resultsAfter 2 years, the 136 participants in high intensity weightbearing exercises developed significantly less radiological damage than the 145 participants in UC. The mean (SD) increase in damage was 3.5 (7.9) in the exercise group and 5.7 (10.2) in the UC group, p = 0.045. Separate analysis of the damage to the hands and feet suggests that this difference in rate of increase of damage is more pronounced in the joints of the feet than in the hands. The rate of damage was independently associated with less disease activity, less frequent use of glucocorticoids, and with an improvement in aerobic fitness.
conclusionThe progression of radiological joint damage of the hands and feet in patients with RA is not increased by long term high intensity weightbearing exercises. These exercises may have a protective effect on the joints of the feet.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.